Solid Pseudopapillary Neoplasms of the Pancreas: a 19-Year Multicenter Experience in China

Overview

Journal J Gastrointest Surg

Specialty Gastroenterology

Date 2015 May 24

PMID 26001371

Citations 31

Authors

Pengfei Yu

Xiangdong Cheng

Yian Du

Litao Yang

Zhiyuan Xu

Wenjuan Yin

Zhengxiang Zhong

Xiaoguang Wang

Hongbao Xu

Conggang Hu

Affiliations

Soon will be listed here.

Abstract

Aim: The aim of this study was to determine the clinicopathological features, surgical management, and prognosis of solid pseudopapillary neoplasms (SPNs) of the pancreas.

Methods: This study conducted a retrospective analysis of 97 patients who underwent surgery for a pathologically confirmed SPN in five hospitals between January 1996 and December 2014.

Results: The 97 cases included 93 female and 4 male patients, and the average age was 31.2 years. The tumor was located in the body or tail (70.1%), the head (20.6%), and the neck (9.3%). All patients underwent surgical exploration, including distal pancreatectomy (63.9%), pancreaticoduodenectomy (20.6%) (partial portal vein or superior mesenteric vein resection and artificial vascular graft reconstruction performed in 4.1% of the patients), central pancreatectomy (10.3%), enucleation (5.2%), and liver resection (1.0%). 16.5% of the patients had malignant tumors. The positive rate of Ki-67 was 66.7% in patients diagnosed with a malignant neoplasm and was comparable to 8.4% of the patients diagnosed to have a benign neoplasm (p < 0.001). After a median follow-up of 70.1 months, three patients had recurrence and one patient died of liver metastasis.

Conclusions: SPN is a rare neoplasm with low malignant potential. Surgical resection is warranted even in the presence of local invasion or metastases as patients demonstrate excellent long-term survival. Positive immunoreactivity for Ki-67 may predict the malignant potential and poor outcome of SPNs.

Citing Articles

Pediatric Solid Pseudopapillary Neoplasm of the Pancreas.

Samuel A, Boddu D, Patricia S, Kodiatte T, Sreekanth K, Hegde P J Indian Assoc Pediatr Surg. 2024; 29(4):345-350.

PMID: 39149425 PMC: 11324080. DOI: 10.4103/jiaps.jiaps_7_24.

Solid pseudopapillary neoplasm of the pancreas with hepatic metastases: problems and strategies.

Li X, Ren J, Ke J, Jiang P, Guo L, Zhang L Front Oncol. 2024; 14:1410888.

PMID: 39099687 PMC: 11294175. DOI: 10.3389/fonc.2024.1410888.

Solid pseudopapillary neoplasm (SPN) of the pancreas: current understanding on its malignant potential and management.

Lu X, Chen H, Zhang T Discov Oncol. 2024; 15(1):77.

PMID: 38498246 PMC: 10948659. DOI: 10.1007/s12672-024-00905-5.

Solid Pseudopapillary Tumor of the Pancreas: Is Enucleation Safe?.

Salirrosas O, Vega E, Panettieri E, Harandi H, Kozyreva O, Ghanta S Ann Surg Oncol. 2024; 31(6):4105-4111.

PMID: 38480561 DOI: 10.1245/s10434-024-15119-w.

Radiomics advances in the evaluation of pancreatic cystic neoplasms.

Mao K, Ma C, Song B Heliyon. 2024; 10(3):e25535.

PMID: 38333791 PMC: 10850586. DOI: 10.1016/j.heliyon.2024.e25535.

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