Cadmium Status Among Pediatric Cancer Patients in Egypt

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2015 May 22

PMID 25997039

Citations 10

Authors

Laila M Sherief

Elhamy R Abdelkhalek

Amal F Gharieb

Hanan S Sherbiny

Doaa M Usef

Mohamed A A Almalky

Naglaa M Kamal

Mostafa A Salama

Wafaa Gohar

Affiliations

Soon will be listed here.

Abstract

Cadmium (Cd) is a toxic, nonessential, and bio-accumulating heavy metal widely used in industry. Several studies have suggested a positive association between Cd exposure and risks of several cancers. However, data from general population, especially children are sparse.In the current cross-sectional case-control study, we aimed to assess the association between Cd exposure, as expressed by Cd body status (blood, urine, scalp hair, and nails) and cancer among Egyptian children. Three hundred and fifty pediatric cancer cases aged 3 to 14-years old were enrolled in our study. Their body Cd levels were evaluated using Atomic Absorption Spectrophometer and were compared with Cd levels of 350 healthy children.Significantly higher Cd levels (blood, urine, scalp hair, and nails) were documented in cancer cases when compared with control (P < 0.001). Such difference was still detected when comparing each malignant type separately, with controls. Tobacco smoke exposure, rural residence, and low socioeconomic status were reported more frequently among cases than comparisons.Positive association between Cd exposure and pediatric malignancy may be present.

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