A Transgenic Drosophila Melanogaster Model To Study Human T-Lymphotropic Virus Oncoprotein Tax-1-Driven Transformation In Vivo

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2015 May 22

PMID 25995252

Citations 18

Authors

Margret Shirinian

Zakaria Kambris

Lama Hamadeh

Caroline Grabbe

Chloe Journo

Renaud Mahieux

Ali Bazarbachi

Affiliations

Soon will be listed here.

Abstract

Human T-cell lymphotropic virus type 1 (HTLV-1)-induced adult T-cell leukemia/lymphoma is an aggressive malignancy. HTLV-2 is genetically related to HTLV-1 but does not cause any malignant disease. HTLV-1 Tax transactivator (Tax-1) contributes to leukemogenesis via NF-κB. We describe transgenic Drosophila models expressing Tax in the compound eye and plasmatocytes. We demonstrate that Tax-1 but not Tax-2 induces ommatidial perturbation and increased plasmatocyte proliferation and that the eye phenotype is dependent on Kenny (IKKγ/NEMO), thus validating this new in vivo model.

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