Endothelium-derived ET-1 and the Development of Renal Injury

Overview

Journal Am J Physiol Regul Integr Comp Physiol

Publisher American Physiological Society

Specialty Physiology

Date 2015 May 22

PMID 25994955

Citations 4

Authors

Carmen De Miguel

David M Pollock

Jennifer S Pollock

Affiliations

Soon will be listed here.

Abstract

The role of the vasoactive peptide endothelin-1 (ET-1) in renal injury is not fully understood. In this review, we examine the genetic models available to understand the autocrine/paracrine mechanisms by which ET-1 leads to renal injury and propose the working hypothesis that endothelium-derived ET-1 induces renal injury by initiating renal tubular apoptosis in a paracrine manner.

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