Transcription Factor Networks in B-cell Differentiation Link Development to Acute Lymphoid Leukemia

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2015 May 21

PMID 25990863

Citations 70

Authors

Rajesh Somasundaram

Mahadesh A J Prasad

Jonas Ungerback

Mikael Sigvardsson

Affiliations

Soon will be listed here.

Abstract

B-lymphocyte development in the bone marrow is controlled by the coordinated action of transcription factors creating regulatory networks ensuring activation of the B-lymphoid program and silencing of alternative cell fates. This process is tightly connected to malignant transformation because B-lineage acute lymphoblastic leukemia cells display a pronounced block in differentiation resulting in the expansion of immature progenitor cells. Over the last few years, high-resolution analysis of genetic changes in leukemia has revealed that several key regulators of normal B-cell development, including IKZF1, TCF3, EBF1, and PAX5, are genetically altered in a large portion of the human B-lineage acute leukemias. This opens the possibility of directly linking the disrupted development as well as aberrant gene expression patterns in leukemic cells to molecular functions of defined transcription factors in normal cell differentiation. This review article focuses on the roles of transcription factors in early B-cell development and their involvement in the formation of human leukemia.

Citing Articles

Mycovirus-Containing Alters Transcription Factors in Normal and Acute Lymphoblastic Leukemia Cells.

Tebbi C, Yan J, Sahakian E, Mediavilla-Varela M, Pinilla-Ibarz J, Patel S Int J Mol Sci. 2024; 25(19).

PMID: 39408690 PMC: 11476453. DOI: 10.3390/ijms251910361.

YY1 knockout in pro-B cells impairs lineage commitment, enabling unusual hematopoietic lineage plasticity.

Banerjee S, Sanyal S, Hodawadekar S, Naiyer S, Bano N, Banerjee A Genes Dev. 2024; 38(17-20):887-914.

PMID: 39362773 PMC: 11535188. DOI: 10.1101/gad.351734.124.

A computational approach for deciphering the interactions between proximal and distal gene regulators in GC B-cell response.

Park S, Nakai K NAR Genom Bioinform. 2024; 6(2):lqae050.

PMID: 38711859 PMC: 11071120. DOI: 10.1093/nargab/lqae050.

Identification of prognostic stemness-related genes in kidney renal papillary cell carcinoma.

Liu Y, Yao Y, Zhang Y, Xu C, Yang T, Qu M BMC Med Genomics. 2024; 17(1):121.

PMID: 38702698 PMC: 11067181. DOI: 10.1186/s12920-024-01870-2.

Oncotherapy resistance explained by Darwinian and Lamarckian models.

Saunthararajah Y J Clin Invest. 2024; 134(8).

PMID: 38618954 PMC: 11014649. DOI: 10.1172/JCI179788.

References

Hunger S . Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis. Blood. 1996; 87(4):1211-24. View

Nutt S, Urbanek P, Rolink A, Busslinger M . Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus. Genes Dev. 1997; 11(4):476-91. DOI: 10.1101/gad.11.4.476. View

Hu M, Krause D, Greaves M, Sharkis S, Dexter M, Heyworth C . Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev. 1997; 11(6):774-85. DOI: 10.1101/gad.11.6.774. View

Doulatov S, Notta F, Eppert K, Nguyen L, Ohashi P, Dick J . Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development. Nat Immunol. 2010; 11(7):585-93. DOI: 10.1038/ni.1889. View

Kuiper R, Waanders E, van der Velden V, van Reijmersdal S, Venkatachalam R, Scheijen B . IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL. Leukemia. 2010; 24(7):1258-64. DOI: 10.1038/leu.2010.87. View

Jo S, Schatz J, Acquaviva J, Singh H, Ren R . Cooperation between deficiencies of IRF-4 and IRF-8 promotes both myeloid and lymphoid tumorigenesis. Blood. 2010; 116(15):2759-67. PMC: 2974585. DOI: 10.1182/blood-2009-07-234559. View

Zhuang Y, Cheng P, Weintraub H . B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. Mol Cell Biol. 1996; 16(6):2898-905. PMC: 231283. DOI: 10.1128/MCB.16.6.2898. View

Busslinger M, Klix N, Pfeffer P, Graninger P, Kozmik Z . Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma. Proc Natl Acad Sci U S A. 1996; 93(12):6129-34. PMC: 39201. DOI: 10.1073/pnas.93.12.6129. View

Iida S, Rao P, Nallasivam P, Hibshoosh H, Butler M, Louie D . The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene. Blood. 1996; 88(11):4110-7. View

10.

Treiber T, Mandel E, Pott S, Gyory I, Firner S, Liu E . Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin. Immunity. 2010; 32(5):714-25. DOI: 10.1016/j.immuni.2010.04.013. View

11.

Carotta S, Dakic A, DAmico A, Pang S, Greig K, Nutt S . The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner. Immunity. 2010; 32(5):628-41. DOI: 10.1016/j.immuni.2010.05.005. View

12.

Heinz S, Benner C, Spann N, Bertolino E, Lin Y, Laslo P . Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010; 38(4):576-89. PMC: 2898526. DOI: 10.1016/j.molcel.2010.05.004. View

13.

Strehl S, Konig M, Dworzak M, Kalwak K, Haas O . PAX5/ETV6 fusion defines cytogenetic entity dic(9;12)(p13;p13). Leukemia. 2003; 17(6):1121-3. DOI: 10.1038/sj.leu.2402923. View

14.

Lu R, Medina K, Lancki D, Singh H . IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development. Genes Dev. 2003; 17(14):1703-8. PMC: 196178. DOI: 10.1101/gad.1104803. View

15.

Zhang Z, Cotta C, Stephan R, deGuzman C, Klug C . Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage. EMBO J. 2003; 22(18):4759-69. PMC: 212730. DOI: 10.1093/emboj/cdg464. View

16.

Maier H, Ostraat R, Gao H, Fields S, Shinton S, Medina K . Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol. 2004; 5(10):1069-77. DOI: 10.1038/ni1119. View

17.

Williams D, Look A, Melvin S, Roberson P, Dahl G, Flake T . New chromosomal translocations correlate with specific immunophenotypes of childhood acute lymphoblastic leukemia. Cell. 1984; 36(1):101-9. DOI: 10.1016/0092-8674(84)90078-3. View

18.

Carroll A, Crist W, PARMLEY R, Roper M, Cooper M, Finley W . Pre-B cell leukemia associated with chromosome translocation 1;19. Blood. 1984; 63(3):721-4. View

19.

Kamps M, Murre C, Sun X, Baltimore D . A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell. 1990; 60(4):547-55. DOI: 10.1016/0092-8674(90)90658-2. View

20.

Hunger S, Galili N, Carroll A, Crist W, Link M, Cleary M . The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias. Blood. 1991; 77(4):687-93. View