Metformin May Improve the Prognosis of Patients with Pancreatic Cancer

Overview

Journal Asian Pac J Cancer Prev

Specialty Oncology

Date 2015 May 20

PMID 25987064

Citations 8

Authors

Jia-Wei Zhang

Qing Sun

Affiliations

Soon will be listed here.

Abstract

Background: Pancreatic cancer risk is increased in patients with type 2 diabetes, while being reduced by metformin treatment. However, it is unclear whether metformin could be associated with clinical outcomes of patients with pancreatic cancer and concurrent type 2 diabetes.

Materials And Methods: A pooled analysis of 4 publications including 1,429 patients was performed to investigate the association of metformin and overall survival(OS) in patients with pancreatic cancer and concurrent type 2 diabetes.

Results: A borderline significant relative survival benefit was found in metformin treated patients compared with non-metformin treated patients (hazard ratio 0.80; 95% CI: 0.62-1.03).

Conclusions: These results suggest that further investigation is warranted of whether metformin may benefit the survival of patients with pancreatic cancer and concurrent type 2 diabetes.

Citing Articles

Turkish Gastroenterology Association, Pancreas Study Group, Chronic Pancreatitis Committee Consensus Report.

Soyturk M, Bengi G, Oguz D, Kalkan I, Yalniz M, Tahtaci M Turk J Gastroenterol. 2020; 31(Supp1):S1-S41.

PMID: 33210608 PMC: 7752168. DOI: 10.5152/tjg.2020.220920.

Survival Benefit of Metformin Use for Pancreatic Cancer Patients Who Underwent Pancreatectomy: Results From a Meta-Analysis.

Zhang J, Ma J, Guo L, Yuan B, Jiao Z, Li Y Front Med (Lausanne). 2020; 7:282.

PMID: 32850872 PMC: 7406684. DOI: 10.3389/fmed.2020.00282.

Metformin monotherapy for adults with type 2 diabetes mellitus.

Gnesin F, Thuesen A, Kahler L, Madsbad S, Hemmingsen B Cochrane Database Syst Rev. 2020; 6:CD012906.

PMID: 32501595 PMC: 7386876. DOI: 10.1002/14651858.CD012906.pub2.

Metformin Induces Apoptosis and Inhibits Proliferation through the AMP-Activated Protein Kinase and Insulin-like Growth Factor 1 Receptor Pathways in the Bile Duct Cancer Cells.

Lee J, Hong E, Kim J, Jung J, Park S, Koh D J Cancer. 2019; 10(7):1734-1744.

PMID: 31205529 PMC: 6547996. DOI: 10.7150/jca.26380.

The effect of metformin on survival of patients with pancreatic cancer: a meta-analysis.

Li X, Li T, Liu Z, Gou S, Wang C Sci Rep. 2017; 7(1):5825.

PMID: 28724893 PMC: 5517652. DOI: 10.1038/s41598-017-06207-x.