Successful Treatment of Multifoci Nocardial Brain Abscesses: a Case Report and Literature Review

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2015 May 19

PMID 25984673

Citations 3

Authors

Qingsheng Xu

Renya Zhan

Yiping Feng

Jiajia Chen

Affiliations

Soon will be listed here.

Abstract

Brain nocardiosis is a serious opportunistic infection with high mortality. It exists more common in the immunocompromised hosts than the immunocompetent patients. Trimethoprim-sulfamethoxazole (TMP-SMZ) has been mostly considered as the choice of the medical treatment. Linezolid is also newly found to be effective to avoid the invasive surgery. The authors reported a case of patient with multifoci nocardial brain abscesses who failed with the combination of linezolid and TMP-SMZ alone but recovered with the surgery intervention and sequential antibiotics for 2 years. The patient lived a high quality life without recurrence and complications during the 30 months follow-up.Through the literature review, we recommend earlier stereotactic aspiration for diagnosis, combination with surgery intervention and prolonged anti-infection therapy would improve the prognosis.

Citing Articles

Clinical Characteristics and Treatment Outcome of Central Nervous System Nocardiosis: A Systematic Review of Reported Cases.

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Subretinal abscess as an initial presentation of systemic nocardiosis.

Malik M, Ahsan N, Hilal K, Mahmood S, Siddiqui M BMJ Case Rep. 2020; 13(11).

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An unusual calf lesion in an immunocompromised patient.

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