Antimicrobial Residual Effects of Irrigation Regimens with Maleic Acid in Infected Root Canals

Overview

Journal J Biol Res (Thessalon)

Specialty Biology

Date 2015 May 19

PMID 25984506

Citations 3

Authors

Carmen Maria Ferrer-Luque

Silvia Gonzalez-Castillo

Matilde Ruiz-Linares

Maria Teresa Arias-Moliz

Alberto Rodriguez-Archilla

Pilar Baca

Affiliations

Soon will be listed here.

Abstract

Background: The success of endodontic treatment depends largely on the control of microorganisms present in infected root canals. The aim of this study was to determine the residual antimicrobial activity of several final irrigation protocols with 7% maleic acid (MA) alone and combined with chlorhexidine (CHX), cetrimide (CTR) or both, in root canals infected with Enterococcus faecalis. Biofilms of E. faecalis were grown in uniradicular roots for 4 weeks. A total of 72 specimens were divided into 5 experimental groups according to the final irrigation regime used: Group 1: 2.5% NaOCl; Group 2: 7% MA; Group 3: 7% MA + 0.2% CTR; Group 4: 7% MA + 2% CHX; Group 5: 7% MA + 0.2% CTR + 2% CHX; and

Control Group: 0.9% saline solution. Twelve roots (2/group) that were instrumented and not infected served as negative or sterility controls. The proportion of ungrown samples over 60 days was evaluated using non-parametric Kaplan-Meier survival analysis. Differences among groups were tested using the log-rank test (p< 0.05).

Results: The association of MA with CHX and CHX + CTR as final irrigating solutions showed the best results, 5 and 4 samples out of 12, respectively, and without differences between them (p = 0.928), followed by 7% MA + 0.2% CTR with 7 out of 12. The 7% MA (11/12) group showed significant differences with respect to the groups in which MA was combined with CHX (p < 0.005) and CHX + CTR (p < 0.005).

Conclusion: Final irrigating solutions of 7% MA combined with 2% CHX or 2% CHX + 0.2% CTR were found to effectively improve antimicrobial root canal disinfection.

Citing Articles

The Effect of Different Final Irrigation Regimens on the Dentinal Tubule Penetration of Three Different Root Canal Sealers: A Confocal Laser Scanning Microscopy Study .

Ozasir T, Eren B, Gulsahi K, Ungor M Scanning. 2021; 2021:8726388.

PMID: 34737843 PMC: 8531796. DOI: 10.1155/2021/8726388.

Comparative evaluation of substantivity of two biguanides - 0.2% polyhexanide and 2% chlorhexidine on human dentin.

Chandki R, Nikhil V, Kalyan S J Conserv Dent. 2020; 23(1):46-50.

PMID: 33223641 PMC: 7657421. DOI: 10.4103/JCD.JCD_256_19.

Update of the therapeutic planning of irrigation and intracanal medication in root canal treatment. A literature review.

Prada I, Mico-Munoz P, Giner-Lluesma T, Mico-Martinez P, Muwaquet-Rodriguez S, Albero-Monteagudo A J Clin Exp Dent. 2019; 11(2):e185-e193.

PMID: 30805124 PMC: 6383907. DOI: 10.4317/jced.55560.

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