» Articles » PMID: 25976960

Assessing Nonvitamin K Antagonist Oral Anticoagulants (NOACs) in the Laboratory

Overview
Specialty Hematology
Date 2015 May 16
PMID 25976960
Citations 4
Authors
Affiliations
Soon will be listed here.
Abstract

Nonvitamin K antagonist oral anticoagulants (NOACs) are being used with increasing frequency due to their safety profile, ease of use, and given that therapeutic monitoring is not required. As these agents have only recently been FDA approved, their effect on routine and specialty coagulation assays is not well appreciated. This article discusses NOAC effect on routine coagulation assays and whether these assays can be used to estimate drug concentration as well as which assays are suitable to quantitate drug concentration in plasma. Also reviewed is the use of manufactured drug calibrators to determine reagent responsiveness and the effect of these agents on various special coagulation assays.

Citing Articles

NOACs in Anesthesiology.

Spahn D, Beer J, Borgeat A, Chassot P, Kern C, Mach F Transfus Med Hemother. 2019; 46(4):282-293.

PMID: 31700511 PMC: 6739714. DOI: 10.1159/000491400.


Specific reversal agents: Fast and fearless - A new era in anticoagulation care.

Bhave A Indian J Anaesth. 2019; 63(3):167-168.

PMID: 30988529 PMC: 6423936. DOI: 10.4103/ija.IJA_109_19.


Contemporary utilization of antithrombotic therapy for stroke prevention in patients with atrial fibrillation: an audit in an Australian hospital setting.

Pandya E, Anderson E, Chow C, Wang Y, Bajorek B Ther Adv Drug Saf. 2018; 9(2):97-111.

PMID: 29387335 PMC: 5772521. DOI: 10.1177/2042098617744926.


[Monitoring of NOAC].

Zotz R, Weissbach L Med Klin Intensivmed Notfmed. 2017; 112(2):92-98.

PMID: 28083625 DOI: 10.1007/s00063-016-0249-6.