Stem Cells for the Cell and Molecular Therapy of Type 1 Diabetes Mellitus (T1D): the Gap Between Dream and Reality

Overview

Journal Am J Stem Cells

Date 2015 May 15

PMID 25973328

Citations 5

Authors

Riccardo Calafiore

Giuseppe Basta

Affiliations

Soon will be listed here.

Abstract

In spite of intense research, over the past 2-3 decades, targeted to validating methods for the cure of T1D, based on cell substitution therapy in the place of exogenously administered insulin injections, achievement of the final goal continues to remain out of reach. In fact, aside of very limited clinical success of the few clinical trials of pancreatic islet cell transplantation in totally immunosuppressed patients with T1D, the vast majority of these diabetic patients invariably is insulin-dependent. New advances for cell and molecular therapy for T1D, including use of stem cells, are reviewed and discussed in an attempt to clearly establish where we are and where are we may go for the final cure for T1DM.

Citing Articles

Co-transplantation of Human Fetal Mesenchymal and Hematopoietic Stem Cells in Type 1 Diabetic Mice Model.

Arjmand B, Goodarzi P, Aghayan H, Payab M, Rahim F, Alavi-Moghadam S Front Endocrinol (Lausanne). 2019; 10:761.

PMID: 31781036 PMC: 6856665. DOI: 10.3389/fendo.2019.00761.

Applications of stem cells and bioprinting for potential treatment of diabetes.

Kumar S, Delgado M, Mendez V, Joddar B World J Stem Cells. 2019; 11(1):13-32.

PMID: 30705712 PMC: 6354103. DOI: 10.4252/wjsc.v11.i1.13.

Adult muscle-derived stem cells engraft and differentiate into insulin-expressing cells in pancreatic islets of diabetic mice.

Mitutsova V, Yeo W, Davaze R, Franckhauser C, Hani E, Abdullah S Stem Cell Res Ther. 2017; 8(1):86.

PMID: 28420418 PMC: 5395782. DOI: 10.1186/s13287-017-0539-9.

Mesenchymal Stem and Progenitor Cells in Regeneration: Tissue Specificity and Regenerative Potential.

Rohban R, Pieber T Stem Cells Int. 2017; 2017:5173732.

PMID: 28286525 PMC: 5327785. DOI: 10.1155/2017/5173732.

Role of stem cells during diabetic liver injury.

Wan Y, Garner J, Wu N, Phillip L, Han Y, McDaniel K J Cell Mol Med. 2015; 20(2):195-203.

PMID: 26645107 PMC: 4727564. DOI: 10.1111/jcmm.12723.

References

Ashcroft F, Rorsman P . Diabetes mellitus and the β cell: the last ten years. Cell. 2012; 148(6):1160-71. PMC: 5890906. DOI: 10.1016/j.cell.2012.02.010. View

Weiss M, Medicetty S, Bledsoe A, Rachakatla R, Choi M, Merchav S . Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease. Stem Cells. 2005; 24(3):781-92. DOI: 10.1634/stemcells.2005-0330. View

Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K . Induced pluripotent stem cells generated without viral integration. Science. 2008; 322(5903):945-9. PMC: 3987909. DOI: 10.1126/science.1162494. View

Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T . Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol. 2007; 26(1):101-6. DOI: 10.1038/nbt1374. View

Xu X, Browning V, Odorico J . Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells. Mech Dev. 2011; 128(7-10):412-27. PMC: 3225072. DOI: 10.1016/j.mod.2011.08.001. View

Calafiore R, Basta G, Luca G, Lemmi A, Montanucci M, Calabrese G . Microencapsulated pancreatic islet allografts into nonimmunosuppressed patients with type 1 diabetes: first two cases. Diabetes Care. 2005; 29(1):137-8. DOI: 10.2337/diacare.29.1.137. View

Kern S, Eichler H, Stoeve J, Kluter H, Bieback K . Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells. 2006; 24(5):1294-301. DOI: 10.1634/stemcells.2005-0342. View

Zhu F, Zhang P, Zhang D, Sui X, Yin M, Xiang T . Generation of pancreatic insulin-producing cells from rhesus monkey induced pluripotent stem cells. Diabetologia. 2011; 54(9):2325-36. DOI: 10.1007/s00125-011-2246-x. View

Yamanaka S . Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell. 2008; 1(1):39-49. DOI: 10.1016/j.stem.2007.05.012. View

10.

ZuK P, Zhu M, Ashjian P, De Ugarte D, Huang J, Mizuno H . Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002; 13(12):4279-95. PMC: 138633. DOI: 10.1091/mbc.e02-02-0105. View

11.

Elliott R, Escobar L, Tan P, Muzina M, Zwain S, Buchanan C . Live encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation. Xenotransplantation. 2007; 14(2):157-61. DOI: 10.1111/j.1399-3089.2007.00384.x. View

12.

Knoepfler P . Why myc? An unexpected ingredient in the stem cell cocktail. Cell Stem Cell. 2008; 2(1):18-21. DOI: 10.1016/j.stem.2007.12.004. View

13.

Dufrane D, Gianello P . Pig islet xenotransplantation into non-human primate model. Transplantation. 2008; 86(6):753-60. DOI: 10.1097/TP.0b013e3181840f55. View

14.

Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R . Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science. 2001; 292(5520):1389-94. DOI: 10.1126/science.1058866. View

15.

Gradwohl G, Dierich A, Lemeur M, Guillemot F . neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A. 2000; 97(4):1607-11. PMC: 26482. DOI: 10.1073/pnas.97.4.1607. View

16.

Okita K, Ichisaka T, Yamanaka S . Generation of germline-competent induced pluripotent stem cells. Nature. 2007; 448(7151):313-7. DOI: 10.1038/nature05934. View

17.

Puri S, Hebrok M . Cellular plasticity within the pancreas--lessons learned from development. Dev Cell. 2010; 18(3):342-56. PMC: 4085547. DOI: 10.1016/j.devcel.2010.02.005. View

18.

Delorme B, Ringe J, Gallay N, Le Vern Y, Kerboeuf D, Jorgensen C . Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cells. Blood. 2007; 111(5):2631-5. DOI: 10.1182/blood-2007-07-099622. View

19.

Baksh D, Yao R, Tuan R . Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells. 2007; 25(6):1384-92. DOI: 10.1634/stemcells.2006-0709. View

20.

Nostro M, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X . Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development. 2011; 138(5):861-71. PMC: 3035090. DOI: 10.1242/dev.055236. View