Melanocortinergic Circuits from Medial Vestibular Nuclei to the Kidney Defined by Transneuronal Transport of Pseudorabies Virus

Overview

Journal Int J Clin Exp Pathol

Specialty Pathology

Date 2015 May 15

PMID 25973095

Citations 3

Authors

Dan Shang

Jun Xiong

Hong-Bing Xiang

Yan Hao

Jiu-Hong Liu

Affiliations

Soon will be listed here.

Abstract

This study was designed to assess whether MC4R signaling existed in vestibular nuclei modulated the activity of kidney by a virally mediated transsynaptic tracing study. Pseudorabies virus (PRV)-614 was injected into the kidney in adult male MC4R-green fluorescent protein (GFP) transgenic mice (n = 5). After a survival time of 5 days, the mice were assigned to humanely sacrifice, and the brainstem were removed and sectioned, and processed for PRV-614 visualization. The neurochemical phenotype of MC4R-GFP-positive neurons was identified using fluorescence immunocytochemical labeling. PRV-614/MC4R-GFP dual labeled neurons were detected in medial vestibular nuclei. Our findings support the hypothesis that there exist melanocortinergic circuits from medial vestibular nuclei to the kidney.

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