A Systems Approach to Elucidate Heterosis of Protein Abundances in Yeast

Overview

Journal Mol Cell Proteomics

Specialties Biochemistry
Cell Biology
Molecular Biology

Date 2015 May 15

PMID 25971257

Citations 20

Authors

Melisande Blein-Nicolas

Warren Albertin

Telma Da Silva

Benoit Valot

Thierry Balliau

Isabelle Masneuf-Pomarede

Marina Bely

Philippe Marullo

Delphine Sicard

Christine Dillmann

Dominique de Vienne

Michel Zivy

Affiliations

Soon will be listed here.

Abstract

Heterosis is a universal phenomenon that has major implications in evolution and is of tremendous agro-economic value. To study the molecular manifestations of heterosis and to find factors that maximize its strength, we implemented a large-scale proteomic experiment in yeast. We analyzed the inheritance of 1,396 proteins in 55 inter- and intraspecific hybrids obtained from Saccharomyces cerevisiae and S. uvarum that were grown in grape juice at two temperatures. We showed that the proportion of heterotic proteins was highly variable depending on the parental strain and on the temperature considered. For intraspecific hybrids, this proportion was higher at nonoptimal temperature. Unexpectedly, heterosis for protein abundance was strongly biased toward positive values in interspecific hybrids but not in intraspecific hybrids. Computer modeling showed that this observation could be accounted for by assuming concave relationships between protein abundances and their controlling factors, in line with the metabolic model of heterosis. These results point to nonlinear processes that could play a central role in heterosis.

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