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The Role of Physical Rehabilitation in Stem Cell Transplantation Patients

Overview
Specialties Critical Care
Oncology
Date 2015 May 15
PMID 25971213
Citations 14
Authors
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Abstract

The purpose of this paper is to review the evidence for the role of physical rehabilitation in stem cell transplantation patients. We will also review the literature and discuss professional experiences on how rehabilitation can play a role in stem cell transplant care and survivorship. Hematopoietic stem cell transplantation (HCT) is a procedure that has evolved substantially over the years to help treat multiple conditions, particularly hematologic malignancies. HCT can be very stressful on the body and can leave patients weakened and sometimes quite debilitated. Supportive care measures have advanced to improve the quality of life and overall survival of HCT survivors. One key component of improved supportive care is gaining increased attention, and that is physical medicine and rehabilitation. Its role in HCT survivorship care is expanding, and new insight and research within the discipline have focused on fatigue, inflammation, exercise, and the development of structured rehabilitation programs to improve the musculoskeletal sequelae of transplantation. This literature review has demonstrated the utility of physical rehabilitation in HCT, its impact on cancer-related fatigue, and to outline the current state of the literature on these topics. The paper delves into a background of HCT. Cancer-related fatigue in HCT is then discussed and summarized, and the role that exercise plays in modifying such fatigue is outlined. We then outline the models and the impact that physical rehabilitation may play in HCT recipients.

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References
1.
Hjermstad M, Knobel H, Brinch L, Fayers P, Loge J, Holte H . A prospective study of health-related quality of life, fatigue, anxiety and depression 3-5 years after stem cell transplantation. Bone Marrow Transplant. 2004; 34(3):257-66. DOI: 10.1038/sj.bmt.1704561. View

2.
Danaher E, Ferrans C, Verlen E, Ravandi F, Van Besien K, Gelms J . Fatigue and physical activity in patients undergoing hematopoietic stem cell transplant. Oncol Nurs Forum. 2006; 33(3):614-24. DOI: 10.1188/06.ONF.614-624. View

3.
Dimeo F, Fetscher S, Lange W, Mertelsmann R, KEUL J . Effects of aerobic exercise on the physical performance and incidence of treatment-related complications after high-dose chemotherapy. Blood. 1997; 90(9):3390-4. View

4.
Jarden M, Baadsgaard M, Hovgaard D, Boesen E, Adamsen L . A randomized trial on the effect of a multimodal intervention on physical capacity, functional performance and quality of life in adult patients undergoing allogeneic SCT. Bone Marrow Transplant. 2009; 43(9):725-37. DOI: 10.1038/bmt.2009.27. View

5.
Mitchell S . Cancer-related fatigue: state of the science. PM R. 2010; 2(5):364-83. DOI: 10.1016/j.pmrj.2010.03.024. View