The Association Between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 Among Coronary Artery Disease Patients

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2015 May 14

PMID 25969834

Citations 10

Authors

Nasser M Rizk

Ayman El-Menyar

Huda Egue

Idil Souleman Wais

Hissa Mohamed Baluli

Khalid Alali

Fathi Farag

Noura Younes

Jassim Al Suwaidi

Affiliations

Soon will be listed here.

Abstract

Background: Several polymorphisms of a locus on chromosome 1p13.3 have a significant effect on low-density lipoprotein cholesterol (LDL-C), atherosclerosis, and acute coronary syndrome (ACS).

Methods: We aimed to investigate the association between rs599839, rs646776, and rs4970834 of locus 1p13.3 and serum LDL-C and severity of coronary artery stenosis in ACS patients. Genotyping of the rs599839, rs646776, and rs4970834 polymorphisms was performed on Arab patients undergoing coronary angiography for ACS. Patients were divided into group A (ACS with insignificant stenosis (<50%)) and group B (with significant stenosis (≥ 50%)).

Results: Patients carrying the minor G allele in rs599839 had significantly lower mean of LDL-C (2.58 versus 3.44 mM, P = 0.026) than homozygous A allele carriers (GG versus AA). Carriers of minor C allele in rs64776 had significantly higher mean of HDL-C (2.16 versus 1.36 mM, P = 0.004) than carriers of the T alleles (AA versus GG). The odd ratio and 95% confidence interval for dominant model for G allele carriers of rs599839 were 0.51 (0.30-0.92), P = 0.038, among patients with significant stenosis.

Conclusions: Polymorphisms rs646776 and rs599839 of locus 1p13.3 were significantly associated with LDL-C and other lipid parameters. In addition, the G-allele carriers of variant rs599839 had a significant protective effect against the atherosclerosis.

Citing Articles

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Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar.

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Association between Genetic Variants of and Cardiovascular Diseases: A Systematic Review and Meta-Analysis.

Castillo-Avila R, Gonzalez-Castro T, Tovilla-Zarate C, Martinez-Magana J, Lopez-Narvaez M, Juarez-Rojop I J Cardiovasc Dev Dis. 2023; 10(3).

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A Genetic Variant in Proline and Serine Rich Coiled-Coil 1 Gene Is Associated with the Risk of Cardiovascular Disease.

Khorrami M, Sadabadi F, Pasdar A, Safarian-Bana H, Amerizadeh F, Esmaeily H Rep Biochem Mol Biol. 2022; 10(4):653-663.

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