Cytoskeletal Dynamics: a View from the Membrane

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2015 May 13

PMID 25963816

Citations 81

Authors

Magdalena Bezanilla

Amy S Gladfelter

David R Kovar

Wei-Lih Lee

Affiliations

Soon will be listed here.

Abstract

Many aspects of cytoskeletal assembly and dynamics can be recapitulated in vitro; yet, how the cytoskeleton integrates signals in vivo across cellular membranes is far less understood. Recent work has demonstrated that the membrane alone, or through membrane-associated proteins, can effect dynamic changes to the cytoskeleton, thereby impacting cell physiology. Having identified mechanistic links between membranes and the actin, microtubule, and septin cytoskeletons, these studies highlight the membrane's central role in coordinating these cytoskeletal systems to carry out essential processes, such as endocytosis, spindle positioning, and cellular compartmentalization.

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