Megakaryocyte Rupture for Acute Platelet Needs

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2015 May 13

PMID 25963815

Citations 4

Authors

Bernhard Nieswandt

Simon Stritt

Affiliations

Soon will be listed here.

Abstract

Circulating platelets were thought to arise solely from the protrusion and fragmentation of megakaryocyte cytoplasm. Now, Nishimura et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201410052) show that platelet release from megakaryocytes can be induced by interleukin-1α (IL-1α) via a new rupture mechanism, which yields higher platelet numbers, occurs independently of the key regulator of megakaryopoiesis thrombopoietin, and may occur during situations of acute platelet need.

Citing Articles

Megakaryocyte in sepsis: the trinity of coagulation, inflammation and immunity.

Hua T, Yao F, Wang H, Liu W, Zhu X, Yao Y Crit Care. 2024; 28(1):442.

PMID: 39741325 PMC: 11689543. DOI: 10.1186/s13054-024-05221-6.

Interleukins in Platelet Biology: Unraveling the Complex Regulatory Network.

Huang M, Wang L, Zhang Q, Zhou L, Liao R, Wu A Pharmaceuticals (Basel). 2024; 17(1).

PMID: 38256942 PMC: 10820339. DOI: 10.3390/ph17010109.

The bone marrow niche from the inside out: how megakaryocytes are shaped by and shape hematopoiesis.

Stone A, Nascimento T, Barrachina M Blood. 2021; 139(4):483-491.

PMID: 34587234 PMC: 8938937. DOI: 10.1182/blood.2021012827.

Skin telocytes versus fibroblasts: two distinct dermal cell populations.

Kang Y, Zhu Z, Zheng Y, Wan W, Manole C, Zhang Q J Cell Mol Med. 2015; 19(11):2530-9.

PMID: 26414534 PMC: 4627559. DOI: 10.1111/jcmm.12671.

References

Nishimura S, Nagasaki M, Kunishima S, Sawaguchi A, Sakata A, Sakaguchi H . IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs. J Cell Biol. 2015; 209(3):453-66. PMC: 4427781. DOI: 10.1083/jcb.201410052. View

Ng A, Kauppi M, Metcalf D, Hyland C, Josefsson E, Lebois M . Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation. Proc Natl Acad Sci U S A. 2014; 111(16):5884-9. PMC: 4000844. DOI: 10.1073/pnas.1404354111. View

Zhang L, Orban M, Lorenz M, Barocke V, Braun D, Urtz N . A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. J Exp Med. 2012; 209(12):2165-81. PMC: 3501353. DOI: 10.1084/jem.20121090. View

Bender M, Stritt S, Nurden P, van Eeuwijk J, Zieger B, Kentouche K . Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. Nat Commun. 2014; 5:4746. DOI: 10.1038/ncomms5746. View

Kaufman R, AIRO R, Pollack S, CROSBY W . Circulating megakaryocytes and platelet release in the lung. Blood. 1965; 26(6):720-31. View