Depression Increases the Onset of Cardiovascular Disease over and Above Other Determinants in Older Primary Care Patients, a Cohort Study

Overview

Journal BMC Cardiovasc Disord

Publisher Biomed Central

Specialty Cardiology & Vascular Diseases

Date 2015 May 13

PMID 25962398

Citations 13

Authors

Harm W J van Marwijk

Koen G van der Kooy

Coen D A Stehouwer

Aartjan T F Beekman

Hein P J Van Hout

Affiliations

Soon will be listed here.

Abstract

Background: To determine if major depressive disorder (MDD) in older primary care patients is an independent risk factor for cardiovascular events.

Methods: A cohort of 143 primary care patients with depression and 139 non-depressed controls without depression (both aged over 55 years, matched for age and gender) from the Netherlands was evaluated for 2 years. MDD was diagnosed according to DSM-IV-criteria. During the follow-up period, information was collected on physical health, depression status and behavioural risk factors. CVD end points were assessed with validated annual questionnaires and were crosschecked with medical records.

Results: Thirty-four participants experienced a cardiovascular event, of which 71% were depressed: 27/134 with MDD (20.1%) and 9/137 controls (6.6%). MDD was associated with a hazard ratio of 2.83 (p value 0,004, 95% CI 1.32 to 6.05) for cardiovascular events. After adjustment for cardiovascular medication, the hazard ratio was 2.46 (95% CI 1.14 to 5.30).

Conclusions: In a 2-year follow-up period, baseline MDD increased the risk for CVD in older primary care patients compared with controls, over and above well-known cardiovascular risk factors.

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