Hitting the Sweet Spot-glycans As Targets of Fungal Defense Effector Proteins

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2015 May 9

PMID 25955890

Citations 19

Authors

Markus Kunzler

Affiliations

Soon will be listed here.

Abstract

Organisms which rely solely on innate defense systems must combat a large number of antagonists with a comparably low number of defense effector molecules. As one solution of this problem, these organisms have evolved effector molecules targeting epitopes that are conserved between different antagonists of a specific taxon or, if possible, even of different taxa. In order to restrict the activity of the defense effector molecules to physiologically relevant taxa, these target epitopes should, on the other hand, be taxon-specific and easily accessible. Glycans fulfill all these requirements and are therefore a preferred target of defense effector molecules, in particular defense proteins. Here, we review this defense strategy using the example of the defense system of multicellular (filamentous) fungi against microbial competitors and animal predators.

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