Anal Human Papillomavirus and HIV: A Cross-sectional Study Among Men Who Have Sex with Men in Moscow, Russia, 2012-2013

Overview

Journal Euro Surveill

Specialty Infectious Diseases

Date 2015 May 9

PMID 25953132

Citations 5

Authors

A L Wirtz

C E Zelaya

A Peryshkina

I McGowan

R D Cranston

C Latkin

N Galai

V Mogilniy

P Dzhigun

I Kostetskaya

C Beyrer

Affiliations

Soon will be listed here.

Abstract

Anal human papillomavirus (HPV) is prevalent among men who have sex with men (MSM), but has not been studied in the Russian Federation. A cross-sectional survey and HPV genotyping were conducted among HIV seropositive (n=58) and seronegative MSM (n=65)in Moscow. Multivariable logistic regression was performed to identify correlates of infection with oncogenic HPV genotypes 16 and/or 18 (HPV 16/18). Forty per cent (49/124) of all MSM were infected with at least one anal HPV genotype, 31.5% (39/124) had HPV16/18,and 11.5% (14/121) had high-grade squamous intraepithelial lesions (HSIL). HPV 16/18 was more prevalent in HIV seropositive than seronegative men (24/58,41.4% vs 15/65, 23.1%; p=0.03). HIV infection was independently associated with HPV 16/18 (adjusted odds ratio (AOR): 5.08; 95% confidence intervals (CI):1.49-17.34, p=0.01), as was having 2-4 steady male sex partners in the last year (vs ≤ 1 partner; AOR: 6.99;95%CI: 1.94–25.24, p<0.01). History of prison/detention,migration to/within Russia and use of incompatible lubricants were marginally associated with HPV16/18 (p<0.10). Comprehensive prevention options are needed to address HIV and HPV infection among MSM in Russia and may benefit from inclusion of young men in piloted HPV vaccination programmes.

Citing Articles

The Prevalence of High Carcinogenic Risk of HPV Genotypes among HIV-Positive and HIV-Negative MSM from Russia.

Beliakov I, Senina M, Tyulenev Y, Novoselova E, Surovtsev V, Guschin A Can J Infect Dis Med Microbiol. 2021; 2021:6641888.

PMID: 34122681 PMC: 8189766. DOI: 10.1155/2021/6641888.

ART is key to clearing oncogenic HPV genotypes (HR-HPV) in anal mucosa of HIV-positive MSM.

Hidalgo-Tenorio C, Gil-Anguita C, Lopez Ruz M, Omar M, Lopez-Hidalgo J, Pasquau J PLoS One. 2019; 14(10):e0224183.

PMID: 31648254 PMC: 6813028. DOI: 10.1371/journal.pone.0224183.

The prevalence of human papillomavirus infections and associated risk factors in men-who-have-sex-with-men in Cape Town, South Africa.

Muller E, Rebe K, Chirwa T, Struthers H, McIntyre J, Lewis D BMC Infect Dis. 2016; 16(1):440.

PMID: 27549219 PMC: 4994415. DOI: 10.1186/s12879-016-1706-9.

Comparison of Respondent Driven Sampling Estimators to Determine HIV Prevalence and Population Characteristics among Men Who Have Sex with Men in Moscow, Russia.

Wirtz A, Mehta S, Latkin C, Zelaya C, Galai N, Peryshkina A PLoS One. 2016; 11(6):e0155519.

PMID: 27248818 PMC: 4889072. DOI: 10.1371/journal.pone.0155519.

The HIV care continuum among men who have sex with men in Moscow, Russia: a cross-sectional study of infection awareness and engagement in care.

Wirtz A, Zelaya C, Latkin C, Peryshkina A, Galai N, Mogilniy V Sex Transm Infect. 2015; 92(2):161-7.

PMID: 26297721 PMC: 4889127. DOI: 10.1136/sextrans-2015-052076.

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