Perioperative Chlorhexidine Allergy: Is It Serious?

Overview

Journal J Anaesthesiol Clin Pharmacol

Specialty Anesthesiology

Date 2015 May 8

PMID 25948892

Citations 13

Authors

Claude Abdallah

Affiliations

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Abstract

Chlorhexidine is an antiseptic agent, commonly used, in many different preparations, and for multiple purposes. Despite its superior antimicrobial properties, chlorhexidine is a potentially allergenic substance. The following is a review of the current evidence-based knowledge of allergic reactions to chlorhexidine associated with surgical and interventional procedures.

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References

Michalska-Krzanowska G . Anaphylactic reactions during anaesthesia and the perioperative period. Anaesthesiol Intensive Ther. 2012; 44(2):104-11. View

Nagendran V, Wicking J, Ekbote A, Onyekwe T, Garvey L . IgE-mediated chlorhexidine allergy: a new occupational hazard?. Occup Med (Lond). 2009; 59(4):270-2. DOI: 10.1093/occmed/kqp042. View

Liippo J, Kousa P, Lammintausta K . The relevance of chlorhexidine contact allergy. Contact Dermatitis. 2011; 64(4):229-34. DOI: 10.1111/j.1600-0536.2010.01851.x. View

McNeill O, Kerridge R, Boyle M . Review of procedures for investigation of anaesthesia-associated anaphylaxis in Newcastle, Australia. Anaesth Intensive Care. 2008; 36(2):201-7. DOI: 10.1177/0310057X0803600210. View

Garvey L, Roed-Petersen J, Husum B . Anaphylactic reactions in anaesthetised patients - four cases of chlorhexidine allergy. Acta Anaesthesiol Scand. 2001; 45(10):1290-4. DOI: 10.1034/j.1399-6576.2001.451020.x. View

Knudsen B, Avnstorp C . Chlorhexidine gluconate and acetate in patch testing. Contact Dermatitis. 1991; 24(1):45-9. DOI: 10.1111/j.1600-0536.1991.tb01629.x. View

Pham N, Weiner J, Reisner G, Baldo B . Anaphylaxis to chlorhexidine. Case report. Implication of immunoglobulin E antibodies and identification of an allergenic determinant. Clin Exp Allergy. 2000; 30(7):1001-7. DOI: 10.1046/j.1365-2222.2000.00887.x. View

Thong B, Yeow-Chan . Anaphylaxis during surgical and interventional procedures. Ann Allergy Asthma Immunol. 2004; 92(6):619-28. DOI: 10.1016/S1081-1206(10)61427-5. View

Garvey L, Kroigaard M, Poulsen L, Stahl Skov P, Mosbech H, Venemalm L . IgE-mediated allergy to chlorhexidine. J Allergy Clin Immunol. 2007; 120(2):409-15. DOI: 10.1016/j.jaci.2007.04.029. View

10.

Nakonechna A, Dore P, Dixon T, Khan S, Deacock S, Holding S . Immediate hypersensitivity to chlorhexidine is increasingly recognised in the United Kingdom. Allergol Immunopathol (Madr). 2012; 42(1):44-9. DOI: 10.1016/j.aller.2012.08.001. View

11.

Garvey L, Roed-Petersen J, Menne T, Husum B . Danish Anaesthesia Allergy Centre - preliminary results. Acta Anaesthesiol Scand. 2001; 45(10):1204-9. DOI: 10.1034/j.1399-6576.2001.451005.x. View

12.

Kroigaard M, Garvey L, Menne T, Husum B . Allergic reactions in anaesthesia: are suspected causes confirmed on subsequent testing?. Br J Anaesth. 2005; 95(4):468-71. DOI: 10.1093/bja/aei198. View

13.

Antunes J, Kochuyt A, Ceuppens J . Perioperative allergic reactions: experience in a Flemish referral centre. Allergol Immunopathol (Madr). 2013; 42(4):348-54. DOI: 10.1016/j.aller.2013.08.001. View

14.

Sanchez Palacios A, Ortiz Ponce M, Rodriguez Perez A . [Allergic reactions and pseudoallergies in surgical interventions with general anesthesia]. Allergol Immunopathol (Madr). 2000; 28(1):24-36. View

15.

Keni N, Aras M, Chitre V . Chlorhexidine allergy due to topical application. Indian J Dent Res. 2013; 23(5):674-6. DOI: 10.4103/0970-9290.107393. View

16.

Moneret-Vautrin A, Mertes P . Anaphylaxis to general anesthetics. Chem Immunol Allergy. 2010; 95:180-189. DOI: 10.1159/000315951. View