Duchenne Muscular Dystrophy Carriers. Proton Spin-lattice Relaxation Times of Skeletal Muscles on Magnetic Resonance Imaging

Overview

Journal Neuroradiology

Specialties Neurology
Radiology

Date 1989 Jan 1

PMID 2594178

Citations 6

Authors

K Matsumura

I Nakano

N Fukuda

H Ikehira

Y Tateno

Y Aoki

Affiliations

Soon will be listed here.

Abstract

By means of magnetic resonance imaging (MRI), the proton spin-lattice relaxation times (T1 values) of the skeletal muscles were measured in Duchenne muscular dystrophy (DMD) carriers and normal controls. The bound water fraction (BWF) was calculated form the T1 values obtained, according to the fast proton diffusion model. In the DMD carriers, T1 values of the gluteus maximus and quadriceps femoris muscles were significantly higher, and BWFs of these muscles were significantly lower, than in normal control. Degenerative muscular changes accompanied by interstitial edema were presumed responsible for this abnormality. No correlation was observed between the muscle T1 and serum creatine kinase values. The present study showed that MRI could be a useful method for studying the dynamic state of water in both normal and pathological skeletal muscles. Its possible utility for DMD carrier detection was discussed briefly.

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References

Bonilla E, Samitt C, Miranda A, Hays A, Salviati G, DiMauro S . Duchenne muscular dystrophy: deficiency of dystrophin at the muscle cell surface. Cell. 1988; 54(4):447-52. DOI: 10.1016/0092-8674(88)90065-7. View

Fisher E, Wissinger H, Gerneth J, Danowski T . Ultrastructural changes in skeletal muscle of muscular dystrophy carriers. Arch Pathol. 1972; 94(5):456-60. View

Roy S, Dubowitz V . Carrier detection in Duchenne muscular dystrophy. A comparative study of electron microscopy, light microscopy and serum enzymes. J Neurol Sci. 1970; 11(1):65-79. DOI: 10.1016/0022-510x(70)90041-9. View

Chang D, Misra L, Beall P, FANGUY R, Hazlewood C . Nuclear magnetic resonance study of muscle water protons in muscular dystrophy of chickens. J Cell Physiol. 1981; 107(1):139-45. DOI: 10.1002/jcp.1041070115. View

Pearce G, Pearce J, Walton J . The Duchenne type muscular dystrophy: histopathological studies of the carrier state. Brain. 1966; 89(1):109-20. DOI: 10.1093/brain/89.1.109. View

Koenig M, Monaco A, Kunkel L . The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein. Cell. 1988; 53(2):219-28. DOI: 10.1016/0092-8674(88)90383-2. View

Moser H, EMERY A . The manifesting carrier in Duchenne muscular dystrophy. Clin Genet. 1974; 5(4):271-84. DOI: 10.1111/j.1399-0004.1974.tb01694.x. View

Thompson M, Murphy E, McAlpine P . An assessment of the creatine kinase test in the detection of carriers of Duchenne muscular dystrophy. J Pediatr. 1967; 71(1):82-93. DOI: 10.1016/s0022-3476(67)80235-x. View

Fullerton G, Cameron I, Ord V . Frequency dependence of magnetic resonance spin-lattice relaxation of protons in biological materials. Radiology. 1984; 151(1):135-8. DOI: 10.1148/radiology.151.1.6322223. View

10.

Matsumura K, Nakano I, Fukuda N, Ikehira H, Tateno Y, Aoki Y . Proton spin-lattice relaxation time of Duchenne dystrophy skeletal muscle by magnetic resonance imaging. Muscle Nerve. 1988; 11(2):97-102. DOI: 10.1002/mus.880110202. View

11.

Bulman D, Karpati G, Burghes A, Belfall B, Klamut H, Talbot J . The Duchenne muscular dystrophy gene product is localized in sarcolemma of human skeletal muscle. Nature. 1988; 333(6172):466-9. DOI: 10.1038/333466a0. View

12.

Arahata K, Ishihara T, Kamakura K, Tsukahara T, Ishiura S, Baba C . Mosaic expression of dystrophin in symptomatic carriers of Duchenne's muscular dystrophy. N Engl J Med. 1989; 320(3):138-42. DOI: 10.1056/NEJM198901193200302. View

13.

Hoffman E, Brown Jr R, Kunkel L . Dystrophin: the protein product of the Duchenne muscular dystrophy locus. Cell. 1987; 51(6):919-28. DOI: 10.1016/0092-8674(87)90579-4. View

14.

Ionescu V, Radu H, Nicolescu P . Identification of Duchenne muscular dystrophy carriers. Electron microscopical investigation of skeletal muscle. Arch Pathol. 1975; 99(8):436-41. View