Early Decreased Plasma Levels of Factor B and C5a Are Important Biomarkers in Children with Kawasaki Disease

Overview

Journal Pediatr Res

Specialties Biology
Pediatrics

Date 2015 May 5

PMID 25938736

Citations 2

Authors

Qing-Mei Zou

Xiao-Hui Li

Rui-Xia Song

Nan-Ping Xu

Ting Zhang

Ming-Ming Zhang

Yao Lin

Lin Shi

Jin Fu

Xiao-Dai Cui

Affiliations

Soon will be listed here.

Abstract

Background: The mechanisms underpinning Kawasaki disease (KD) are incompletely understood. There is an unmet need for specific biomarkers for the early diagnosis of KD.

Methods: Eighty-five KD patients suffering from acute-phase and subacute-phase KD, 40 healthy children, and 40 febrile children comprised the study cohort. An enzyme-linked immunosorbent assay was used to measure plasma levels of C1q, C1q-circulating immune complex (C1q-CIC), mannan-binding lectin-associated serine protease (MASP)-1, factor B, C4d, C3d, C5a, C5b-9 and CD59.

Results: Plasma concentrations of factor B and C5a in the acute phase were lower than those in healthy and febrile control groups (all P < 0.05). Compared with acute-phase KD patients, plasma concentrations of C1q, factor B, and C3d in KD patients were increased significantly (P < 0.05), but those of C4d, MASP-1 and CD59 decreased significantly (P < 0.05), in patients with sub-acute KD.

Conclusion: These data suggest that more than one pathway in the complement system is activated in KD. Importantly, decreased plasma concentrations of factor B and C5a in the acute phase (6-10 d) could be employed as biomarkers for the early diagnosis of KD.

Citing Articles

Identification of 10 Hub Genes and an miRNA-mRNA Regulatory Network in Acute Kawasaki Disease.

Ma J, Gui H, Tang Y, Ding Y, Qian G, Yang M Front Genet. 2021; 12:585058.

PMID: 33868359 PMC: 8044791. DOI: 10.3389/fgene.2021.585058.

Does the Lectin Complement Pathway Link Kawasaki Disease and SARS-CoV-2?.

Polycarpou A, Grigoriadou S, Klavinskis L, Sacks S Front Immunol. 2021; 11:604512.

PMID: 33584675 PMC: 7874141. DOI: 10.3389/fimmu.2020.604512.

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