Systemic Mastocytosis: a Rare Cause of Single Vertebral Body Uptake on Bone Scan

Overview

Journal J Radiol Case Rep

Specialty Radiology

Date 2015 May 1

PMID 25926926

Citations 1

Authors

Monzer Chehab

Alexander Copelan

Zaid Al-Faham

Lawrence Bahoura

Ching Yee Oliver Wong

Affiliations

Soon will be listed here.

Abstract

Systemic Mastocytosis is a rare condition characterized by the abnormal proliferation of Mast Cells. Presentation as a solitary vertebral body lesion is extremely uncommon and may be confused with more ominous conditions such as metastasis. Familiarity with the condition can heighten clinical suspicion, direct tissue diagnosis, guide management and indicate appropriate follow up. We present a case of a 64-year-old woman undergoing staging for recently diagnosed breast cancer who was found to have Systemic Mastocytosis of a single vertebral body.

Citing Articles

Systemic mastocytosis revisited with an emphasis on skeletal manifestations.

Leone A, Criscuolo M, Gulli C, Petrosino A, Bianco N, Colosimo C Radiol Med. 2020; 126(4):585-598.

PMID: 33242205 DOI: 10.1007/s11547-020-01306-8.

References

Fritz J, Fishman E, Carrino J, Horger M . Advanced imaging of skeletal manifestations of systemic mastocytosis. Skeletal Radiol. 2012; 41(8):887-97. DOI: 10.1007/s00256-012-1374-9. View

Zettinig G, Becherer A, Szabo M, Uffmann M, Dudczak R, Valent P . FDG positron emission tomography in patients with systemic mastocytosis. AJR Am J Roentgenol. 2002; 179(5):1235-7. DOI: 10.2214/ajr.179.5.1791235. View

Avila N, Ling A, Worobec A, Mican J, Metcalfe D . Systemic mastocytosis: CT and US features of abdominal manifestations. Radiology. 1997; 202(2):367-72. DOI: 10.1148/radiology.202.2.9015059. View

Ramsay D, Stephen S, Borum M, Voltaggio L, Doman D . Mast cells in gastrointestinal disease. Gastroenterol Hepatol (N Y). 2011; 6(12):772-7. PMC: 3033552. View

Valent P, Sperr W, Akin C . How I treat patients with advanced systemic mastocytosis. Blood. 2010; 116(26):5812-7. DOI: 10.1182/blood-2010-08-292144. View

Garcia-Montero A, Jara-Acevedo M, Teodosio C, Sanchez M, Nunez R, Prados A . KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients. Blood. 2006; 108(7):2366-72. DOI: 10.1182/blood-2006-04-015545. View

Roca M, Mota J, Giraldo P, Garcia Erce J . Systemic mastocytosis: MRI of bone marrow involvement. Eur Radiol. 1999; 9(6):1094-7. DOI: 10.1007/s003300050796. View

Greene G, Maurer A . Solitary vertebral body uptake on bone scintigraphy: the "black ivory" vertebrae sign. Semin Nucl Med. 1985; 15(3):317-21. DOI: 10.1016/s0001-2998(85)80008-8. View

Akin C, Metcalfe D . Systemic mastocytosis. Annu Rev Med. 2004; 55:419-32. DOI: 10.1146/annurev.med.55.091902.103822. View

10.

Tomihama R, McEachen J, Kuo P . Imaging of systemic mastocytosis by FDG-PET/CT demonstrates increased activity in cortical bone. Clin Nucl Med. 2008; 33(3):220-3. DOI: 10.1097/RLU.0b013e3181638e5e. View

11.

Patnaik M, Rindos M, Kouides P, Tefferi A, Pardanani A . Systemic mastocytosis: a concise clinical and laboratory review. Arch Pathol Lab Med. 2007; 131(5):784-91. DOI: 10.5858/2007-131-784-SMACCA. View

12.

Arrington E, Eisenberg B, Hartshorne M, Vela S, Dorin R . Nuclear medicine imaging of systemic mastocytosis. J Nucl Med. 1989; 30(12):2046-8. View

13.

Vardiman J, Thiele J, Arber D, Brunning R, Borowitz M, Porwit A . The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009; 114(5):937-51. DOI: 10.1182/blood-2009-03-209262. View

14.

Genovese A, Spadaro G, Triggiani M, Marone G . Clinical advances in mastocytosis. Int J Clin Lab Res. 1995; 25(4):178-88. DOI: 10.1007/BF02592695. View

15.

Droogendijk H, Kluin-Nelemans H, van Doormaal J, Oranje A, van de Loosdrecht A, van Daele P . Imatinib mesylate in the treatment of systemic mastocytosis: a phase II trial. Cancer. 2006; 107(2):345-51. DOI: 10.1002/cncr.21996. View

16.

Pardanani A . Systemic mastocytosis: disease overview, pathogenesis, and treatment. Hematol Oncol Clin North Am. 2012; 26(5):1117-28. DOI: 10.1016/j.hoc.2012.08.001. View

17.

Metcalfe D . Mast cells and mastocytosis. Blood. 2008; 112(4):946-56. PMC: 2515131. DOI: 10.1182/blood-2007-11-078097. View

18.

Groheux D, Espie M, Giacchetti S, Hindie E . Performance of FDG PET/CT in the clinical management of breast cancer. Radiology. 2012; 266(2):388-405. DOI: 10.1148/radiol.12110853. View

19.

Braga F, de Oliviera G, de Melo A, Barbosa L, Fraga J . Indolent systemic mastocytosis: is there a reliable radiographic pattern?. Pediatr Radiol. 2012; 42(8):1017-20. DOI: 10.1007/s00247-011-2324-8. View

20.

Molderings G, Raithel M, Kratz F, Azemar M, Haenisch B, Harzer S . Omalizumab treatment of systemic mast cell activation disease: experiences from four cases. Intern Med. 2011; 50(6):611-5. DOI: 10.2169/internalmedicine.50.4640. View