Twenty-five Loci Form a Continuous Linkage Map of Markers for Human Chromosome 7

Overview

Journal Genomics

Specialty Genetics

Date 1989 Nov 1

PMID 2591968

Citations 11

Authors

G M Lathrop

P OConnell

M Leppert

Y Nakamura

M Farrall

L C Tsui

J M Lalouel

R White

Affiliations

Soon will be listed here.

Abstract

We have constructed a primary genetic linkage map from DNA markers that define 25 loci on chromosome 7. The markers form a continuous linkage group of 141 cM in males and 340 cM in females; female genetic distances were on average more than twofold higher than those in males throughout the chromosome. The average heterozygosity of the loci was 45%. A subset of the markers can be used for efficient application of this map to studies of human genetic disease.

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