Susceptibility-Weighted Imaging Manifestations in the Brain of Wilson's Disease Patients

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Apr 28

PMID 25915414

Citations 13

Authors

Jinjing Yang

Xiaohu Li

Renmin Yang

Xuen Yu

Changliang Yu

Yinfeng Qian

Yongqiang Yu

Affiliations

Soon will be listed here.

Abstract

Purpose: It is well known that patients with Wilson's disease (WD) suffer copper metabolism disorder. However, recent studies point to an additional iron metabolism disorder in WD patients. The purpose of our study was to examine susceptibility-weighted imaging (SWI) manifestations of WD in the brains of WD patients.

Methods: A total of 33 patients with WD and 18 normal controls underwent conventional MRI (Magnetic resonance imaging) and SWI. The phase values were measured on SWI-filtered phase images of the bilateral head of the caudate nuclei, globus pallidus, putamen, thalamus, substantia nigra, and red nucleus. Student's t-tests were used to compare the phase values between WD groups and normal controls.

Results: The mean phase values for the bilateral head of the caudate nuclei, globus pallidus, putamen, thalamus, substantia nigra, and red nucleus were significantly lower than those in the control group (P < 0.001), and bilateral putamen was most strongly affected.

Conclusions: There is paramagnetic mineralization deposition in brain gray nuclei of WD patients and SWI is an effective method to evaluate these structures.

Citing Articles

Parkinson's disease and Parkinsonism syndromes: Evaluating iron deposition in the putamen using magnetic susceptibility MRI techniques - A systematic review and literature analysis.

Mohammadi S, Ghaderi S Heliyon. 2024; 10(7):e27950.

PMID: 38689949 PMC: 11059419. DOI: 10.1016/j.heliyon.2024.e27950.

A weighted cranial diffusion-weighted imaging scale for Wilson's disease.

Wang S, Geng H, Cheng S, Xu C, Zhang R, Wang Y Front Neurosci. 2023; 17:1186053.

PMID: 37650098 PMC: 10463731. DOI: 10.3389/fnins.2023.1186053.

An Updated Overview of the Magnetic Resonance Imaging of Brain Iron in Movement Disorders.

Tambasco N, Nigro P, Chiappiniello A, Paoletti F, Scialpi S, Simoni S Behav Neurol. 2022; 2022:3972173.

PMID: 35251368 PMC: 8894064. DOI: 10.1155/2022/3972173.

Multimodal magnetic resonance imaging analysis in the characteristics of Wilson's disease: A case report and literature review.

Wang Y, Jia Z, Lyu Y, Dong Q, Li S, Hu W Open Life Sci. 2021; 16(1):793-799.

PMID: 34458581 PMC: 8374231. DOI: 10.1515/biol-2021-0071.

Neuroimaging correlates of brain injury in Wilson's disease: a multimodal, whole-brain MRI study.

Shribman S, Bocchetta M, Sudre C, Acosta-Cabronero J, Burrows M, Cook P Brain. 2021; 145(1):263-275.

PMID: 34289020 PMC: 8967100. DOI: 10.1093/brain/awab274.

References

Kim T, Kim I, Kim W, Cheon J, Moon S, Kwon J . MR imaging of the brain in Wilson disease of childhood: findings before and after treatment with clinical correlation. AJNR Am J Neuroradiol. 2006; 27(6):1373-8. PMC: 8133926. View

Young S, Fahmy M, Golding S . Ceruloplasmin, transferrin and apotransferrin facilitate iron release from human liver cells. FEBS Lett. 1997; 411(1):93-6. DOI: 10.1016/s0014-5793(97)00478-x. View

Haacke E, Ayaz M, Khan A, Manova E, Krishnamurthy B, Gollapalli L . Establishing a baseline phase behavior in magnetic resonance imaging to determine normal vs. abnormal iron content in the brain. J Magn Reson Imaging. 2007; 26(2):256-64. DOI: 10.1002/jmri.22987. View

Haacke E, Mittal S, Wu Z, Neelavalli J, Cheng Y . Susceptibility-weighted imaging: technical aspects and clinical applications, part 1. AJNR Am J Neuroradiol. 2008; 30(1):19-30. PMC: 3805391. DOI: 10.3174/ajnr.A1400. View

Zivadinov R, Schirda C, Dwyer M, Haacke M, Weinstock-Guttman B, Menegatti E . Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility-weighted imaging in patients with multiple sclerosis: a pilot case-control study. Int Angiol. 2010; 29(2):158-75. View

Zhang J, Zhang Y, Wang J, Cai P, Luo C, Qian Z . Characterizing iron deposition in Parkinson's disease using susceptibility-weighted imaging: an in vivo MR study. Brain Res. 2010; 1330:124-30. DOI: 10.1016/j.brainres.2010.03.036. View

Lee J, Kim D, Cho J, Park K, Kim S, Baik S . Characterizing paramagnetic signal in a patient with Wilson's disease by susceptibility-weighted imaging. Clin Neurol Neurosurg. 2011; 114(1):47-9. DOI: 10.1016/j.clineuro.2011.07.002. View

Bruehlmeier M, Leenders K, Vontobel P, Calonder C, Antonini A, Weindl A . Increased cerebral iron uptake in Wilson's disease: a 52Fe-citrate PET study. J Nucl Med. 2000; 41(5):781-7. View

Shiono Y, Wakusawa S, Hayashi H, TAKIKAWA T, Yano M, Okada T . Iron accumulation in the liver of male patients with Wilson's disease. Am J Gastroenterol. 2001; 96(11):3147-51. DOI: 10.1111/j.1572-0241.2001.05269.x. View

10.

Fox P . The copper-iron chronicles: the story of an intimate relationship. Biometals. 2003; 16(1):9-40. DOI: 10.1023/a:1020799512190. View

11.

Frazer D, Anderson G . The orchestration of body iron intake: how and where do enterocytes receive their cues?. Blood Cells Mol Dis. 2003; 30(3):288-97. DOI: 10.1016/s1079-9796(03)00039-1. View

12.

Kozic D, Svetel M, Petrovic B, Dragasevic N, Semnic R, Kostic V . MR imaging of the brain in patients with hepatic form of Wilson's disease. Eur J Neurol. 2003; 10(5):587-92. DOI: 10.1046/j.1468-1331.2003.00661.x. View

13.

Hitoshi S, Iwata M, Yoshikawa K . Mid-brain pathology of Wilson's disease: MRI analysis of three cases. J Neurol Neurosurg Psychiatry. 1991; 54(7):624-6. PMC: 1014434. DOI: 10.1136/jnnp.54.7.624. View

14.

King A, Walshe J, Kendall B, Chinn R, Paley M, Wilkinson I . Cranial MR imaging in Wilson's disease. AJR Am J Roentgenol. 1996; 167(6):1579-84. DOI: 10.2214/ajr.167.6.8956601. View

15.

Merle U, Tuma S, Herrmann T, Muntean V, Volkmann M, Gehrke S . Evidence for a critical role of ceruloplasmin oxidase activity in iron metabolism of Wilson disease gene knockout mice. J Gastroenterol Hepatol. 2010; 25(6):1144-50. DOI: 10.1111/j.1440-1746.2009.06173.x. View

16.

Mukhopadhyay C, Attieh Z, Fox P . Role of ceruloplasmin in cellular iron uptake. Science. 1998; 279(5351):714-7. DOI: 10.1126/science.279.5351.714. View

17.

Ogg R, Langston J, Haacke E, Steen R, Taylor J . The correlation between phase shifts in gradient-echo MR images and regional brain iron concentration. Magn Reson Imaging. 1999; 17(8):1141-8. DOI: 10.1016/s0730-725x(99)00017-x. View

18.

Haacke E, Cheng N, House M, Liu Q, Neelavalli J, Ogg R . Imaging iron stores in the brain using magnetic resonance imaging. Magn Reson Imaging. 2005; 23(1):1-25. DOI: 10.1016/j.mri.2004.10.001. View

19.

Sargent P, Farnaud S, Evans R . Structure/function overview of proteins involved in iron storage and transport. Curr Med Chem. 2005; 12(23):2683-93. DOI: 10.2174/092986705774462969. View

20.

Lee J, Yang T, Cho M, Yoon K, Baik S, Han Y . Widespread cerebral cortical mineralization in Wilson's disease detected by susceptibility-weighted imaging. J Neurol Sci. 2011; 313(1-2):54-6. DOI: 10.1016/j.jns.2011.09.031. View