Urinary Tract Infections and Candida Albicans

Overview

Journal Cent European J Urol

Specialty Urology

Date 2015 Apr 28

PMID 25914847

Citations 54

Authors

Payam Behzadi

Elham Behzadi

Reza Ranjbar

Affiliations

Soon will be listed here.

Abstract

Introduction: Urinary tract candidiasis is known as the most frequent nosocomial fungal infection worldwide. Candida albicans is the most common cause of nosocomial fungal urinary tract infections; however, a rapid change in the distribution of Candida species is undergoing. Simultaneously, the increase of urinary tract candidiasis has led to the appearance of antifungal resistant Candida species. In this review, we have an in depth look into Candida albicans uropathogenesis and distribution of the three most frequent Candida species contributing to urinary tract candidiasis in different countries around the world.

Material And Methods: For writing this review, Google Scholar -a scholarly search engine- (http://scholar.google.com/) and PubMed database (http://www.ncbi.nlm.nih.gov/pubmed/) were used. The most recently published original articles and reviews of literature relating to the first three Candida species causing urinary tract infections in different countries and the pathogenicity of Candida albicans were selected and studied.

Results: Although some studies show rapid changes in the uropathogenesis of Candida species causing urinary tract infections in some countries, Candida albicans is still the most important cause of candidal urinary tract infections.

Conclusions: Despite the ranking of Candida albicans as the dominant species for urinary tract candidiasis, specific changes have occurred in some countries. At this time, it is important to continue the surveillance related to Candida species causing urinary tract infections to prevent, control and treat urinary tract candidiasis in future.

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References

Behzadi P, Behzadi E, Yazdanbod H, Aghapour R, Akbari Cheshmeh M, Salehian Omran D . Urinary Tract Infections Associated with Candida albicans. Maedica (Bucur). 2011; 5(4):277-9. PMC: 3152833. View

Helbig S, Achkar J, Jain N, Wang X, Gialanella P, Levi M . Diagnosis and inflammatory response of patients with candiduria. Mycoses. 2012; 56(1):61-9. PMC: 3419311. DOI: 10.1111/j.1439-0507.2012.02201.x. View

Paluchowska P, Tokarczyk M, Bogusz B, Skiba I, Budak A . Molecular epidemiology of Candida albicans and Candida glabrata strains isolated from intensive care unit patients in Poland. Mem Inst Oswaldo Cruz. 2014; 109(4):436-41. PMC: 4155844. DOI: 10.1590/0074-0276140099. View

Wissing H, Ballus J, Bingold T, Nocea G, Krobot K, Kaskel P . Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study. Infect Drug Resist. 2013; 6:15-25. PMC: 3563346. DOI: 10.2147/IDR.S38945. View

Tomczak H, Szalek E, Grzeskowiak E . The problems of urinary tract infections with Candida spp. aetiology in women. Postepy Hig Med Dosw (Online). 2014; 68:1036-9. DOI: 10.5604/17322693.1118989. View

Mayer F, Wilson D, Hube B . Candida albicans pathogenicity mechanisms. Virulence. 2013; 4(2):119-28. PMC: 3654610. DOI: 10.4161/viru.22913. View

Kotb A, Ismail A, Sharafeldeen M, Elsayed E . Chronic prostatitis/chronic pelvic pain syndrome: the role of an antifungal regimen. Cent European J Urol. 2014; 66(2):196-9. PMC: 3936149. DOI: 10.5173/ceju.2013.02.art21. View

Fisher J, Kavanagh K, Sobel J, Kauffman C, Newman C . Candida urinary tract infection: pathogenesis. Clin Infect Dis. 2011; 52 Suppl 6:S437-51. DOI: 10.1093/cid/cir110. View

Kauffman C . Diagnosis and management of fungal urinary tract infection. Infect Dis Clin North Am. 2014; 28(1):61-74. DOI: 10.1016/j.idc.2013.09.004. View

10.

Bukhary Z . Candiduria: a review of clinical significance and management. Saudi J Kidney Dis Transpl. 2008; 19(3):350-60. View

11.

Badiee P, Alborzi A, Joukar M . Molecular assay to detect nosocomial fungal infections in intensive care units. Eur J Intern Med. 2011; 22(6):611-5. DOI: 10.1016/j.ejim.2011.08.025. View

12.

Zarei Mahmoudabadi A, Zarrin M, Kiasat N . Biofilm Formation and Susceptibility to Amphotericin B and Fluconazole in Candida albicans. Jundishapur J Microbiol. 2014; 7(7):e17105. PMC: 4216586. DOI: 10.5812/jjm.17105. View

13.

Almeida A, Shinobu Mesquita C, Svidzinski T, Pires de Oliveira K . Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil. Rev Soc Bras Med Trop. 2013; 46(3):335-9. DOI: 10.1590/0037-8682-0074-2012. View

14.

Sobel J, Fisher J, Kauffman C, Newman C . Candida urinary tract infections--epidemiology. Clin Infect Dis. 2011; 52 Suppl 6:S433-6. DOI: 10.1093/cid/cir109. View

15.

Wu H, Downs D, Ghosh K, Ghosh A, Staib P, Monod M . Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism. FASEB J. 2013; 27(6):2132-44. PMC: 6188231. DOI: 10.1096/fj.12-214353. View

16.

Ferreira A, Prado C, Carvalho R, Dias K, Dias A . Candida albicans and non-C. albicans Candida species: comparison of biofilm production and metabolic activity in biofilms, and putative virulence properties of isolates from hospital environments and infections. Mycopathologia. 2013; 175(3-4):265-72. DOI: 10.1007/s11046-013-9638-z. View

17.

Newman S, Bhugra B, Holly A, Morris R . Enhanced killing of Candida albicans by human macrophages adherent to type 1 collagen matrices via induction of phagolysosomal fusion. Infect Immun. 2005; 73(2):770-7. PMC: 547032. DOI: 10.1128/IAI.73.2.770-777.2005. View

18.

da Silva E, Ruiz L, Matsumoto F, Auler M, Cintra Giudice M, Moreira D . Candiduria in a public hospital of São Paulo (1999-2004): characteristics of the yeast isolates. Rev Inst Med Trop Sao Paulo. 2007; 49(6):349-53. DOI: 10.1590/s0036-46652007000600003. View

19.

Bouza E, San Juan R, Munoz P, Voss A, Kluytmans J . A European perspective on nosocomial urinary tract infections I. Report on the microbiology workload, etiology and antimicrobial susceptibility (ESGNI-003 study). European Study Group on Nosocomial Infections. Clin Microbiol Infect. 2001; 7(10):523-31. DOI: 10.1046/j.1198-743x.2001.00326.x. View

20.

Ozhak-Baysan B, Ogunc D, Colak D, Ongut G, Donmez L, Vural T . Distribution and antifungal susceptibility of Candida species causing nosocomial candiduria. Med Mycol. 2011; 50(5):529-32. DOI: 10.3109/13693786.2011.618996. View