Novel Role of DNA in Neutrophil Extracellular Traps

Overview

Journal Trends Microbiol

Date 2015 Apr 28

PMID 25913613

Citations 6

Authors

Christoph Georg Baums

Maren von Kockritz-Blickwede

Affiliations

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Abstract

Neutrophil extracellular traps (NETs) have been shown to play a crucial role in health and disease. In a recent paper in PLoS Pathogens, Halverson et al. demonstrate that the DNA backbone of NETs contributes to its antibacterial activity and serves as signal for entrapped microbes to employ immune evasion strategies.

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The Role of DNA in the Extracellular Environment: A Focus on NETs, RETs and Biofilms.

Monticolo F, Palomba E, Termolino P, Chiaiese P, de Alteriis E, Mazzoleni S Front Plant Sci. 2021; 11:589837.

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Secor P, Burgener E, Kinnersley M, Jennings L, Roman-Cruz V, Popescu M Front Immunol. 2020; 11:244.

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Neutrophils and Immunity: From Bactericidal Action to Being Conquered.

Teng T, Ji A, Ji X, Li Y J Immunol Res. 2017; 2017:9671604.

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