Optimization of Vitamin D Status After Roux-en-Y Gastric Bypass Surgery in Obese Patients Living in Northern Climate

Overview

Journal Obes Surg

Date 2015 Apr 26

PMID 25910981

Citations 8

Authors

Lingtak-Neander Chan

Charlotte H Neilson

Elizabeth A Kirk

Tiana F Colovos

Diane R Javelli

Saurabh Khandelwal

Affiliations

Soon will be listed here.

Abstract

Background: Patients who undergo bariatric surgery are at risk for micronutrient deficiencies. The aims of this study were to determine the prevalence and predictors of vitamin D deficiency in obese patients residing in the northern climate, and to evaluate the effectiveness of a daily maintenance dose of vitamin D 2000 IU in preventing hypovitaminosis D within 1 year after bariatric surgery.

Methods: A cohort study involving adult patients undergoing RYGB was conducted. Longitudinal changes in serum vitamin D concentrations and clinical parameters were measured and collected.

Results: Data from 134 recipients of RYGB were analyzed. Hypovitaminosis D was identified in 86 patients (64 %), and was significantly affected by seasonal change and the number of comorbidities. Follow-up data were available in 60 patients. Vitamin D sufficiency was achieved in 62.5 % of those patients with baseline vitamin D insufficiency. A dose-response relationship of vitamin D intake was observed, with the most significant increase in 25(OH)D associated with daily vitamin D intakes ≥ 2000 IU.

Conclusions: The prevalence of hypovitaminosis D before RYGB was comparable to patients living in the non-northern climate. Daily vitamin D intake meeting at least 2000 IU is associated with greater improvement in serum vitamin D concentration.

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References

Forrest K, Stuhldreher W . Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res. 2011; 31(1):48-54. DOI: 10.1016/j.nutres.2010.12.001. View

Lagunova Z, Porojnicu A, Vieth R, Lindberg F, Hexeberg S, Moan J . Serum 25-hydroxyvitamin D is a predictor of serum 1,25-dihydroxyvitamin D in overweight and obese patients. J Nutr. 2010; 141(1):112-7. DOI: 10.3945/jn.109.119495. View

Hallersund P, Sjostrom L, Olbers T, Lonroth H, Jacobson P, Wallenius V . Gastric bypass surgery is followed by lowered blood pressure and increased diuresis - long term results from the Swedish Obese Subjects (SOS) study. PLoS One. 2012; 7(11):e49696. PMC: 3510228. DOI: 10.1371/journal.pone.0049696. View

Mechanick J, Youdim A, Jones D, Garvey W, Hurley D, McMahon M . Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient--2013 update: cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American.... Obesity (Silver Spring). 2013; 21 Suppl 1:S1-27. PMC: 4142593. DOI: 10.1002/oby.20461. View

Aasheim E, Bjorkman S, Sovik T, Engstrom M, Hanvold S, Mala T . Vitamin status after bariatric surgery: a randomized study of gastric bypass and duodenal switch. Am J Clin Nutr. 2009; 90(1):15-22. DOI: 10.3945/ajcn.2009.27583. View

Carlin A, Rao D, Meslemani A, Genaw J, Parikh N, Levy S . Prevalence of vitamin D depletion among morbidly obese patients seeking gastric bypass surgery. Surg Obes Relat Dis. 2006; 2(2):98-103. DOI: 10.1016/j.soard.2005.12.001. View

Sjostrom L, Lindroos A, Peltonen M, Torgerson J, Bouchard C, Carlsson B . Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004; 351(26):2683-93. DOI: 10.1056/NEJMoa035622. View

Aarts E, van Groningen L, Horst R, Telting D, van Sorge A, Janssen I . Vitamin D absorption: consequences of gastric bypass surgery. Eur J Endocrinol. 2011; 164(5):827-32. DOI: 10.1530/EJE-10-1126. View

Aasheim E, Hofso D, Hjelmesaeth J, Birkeland K, Bohmer T . Vitamin status in morbidly obese patients: a cross-sectional study. Am J Clin Nutr. 2008; 87(2):362-9. DOI: 10.1093/ajcn/87.2.362. View

10.

Wortsman J, Matsuoka L, Chen T, Lu Z, Holick M . Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000; 72(3):690-3. DOI: 10.1093/ajcn/72.3.690. View

11.

Mahlay N, Verka L, Thomsen K, Merugu S, Salomone M . Vitamin D status before Roux-en-Y and efficacy of prophylactic and therapeutic doses of vitamin D in patients after Roux-en-Y gastric bypass surgery. Obes Surg. 2008; 19(5):590-4. DOI: 10.1007/s11695-008-9698-1. View

12.

Levinson R, Silverman J, Catella J, Rybak I, Jolin H, Isom K . Pharmacotherapy prevention and management of nutritional deficiencies post Roux-en-Y gastric bypass. Obes Surg. 2013; 23(7):992-1000. DOI: 10.1007/s11695-013-0922-2. View

13.

Webb A, Kline L, Holick M . Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab. 1988; 67(2):373-8. DOI: 10.1210/jcem-67-2-373. View

14.

Parikh S, Edelman M, Uwaifo G, Freedman R, Semega-Janneh M, Reynolds J . The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab. 2004; 89(3):1196-9. DOI: 10.1210/jc.2003-031398. View

15.

Lin E, Armstrong-Moore D, Liang Z, Sweeney J, Torres W, Ziegler T . Contribution of adipose tissue to plasma 25-hydroxyvitamin D concentrations during weight loss following gastric bypass surgery. Obesity (Silver Spring). 2010; 19(3):588-94. PMC: 3066031. DOI: 10.1038/oby.2010.239. View

16.

Goldner W, Stoner J, Lyden E, Thompson J, Taylor K, Larson L . Finding the optimal dose of vitamin D following Roux-en-Y gastric bypass: a prospective, randomized pilot clinical trial. Obes Surg. 2008; 19(2):173-179. DOI: 10.1007/s11695-008-9680-y. View

17.

Goldner W, Stoner J, Thompson J, Taylor K, Larson L, Erickson J . Prevalence of vitamin D insufficiency and deficiency in morbidly obese patients: a comparison with non-obese controls. Obes Surg. 2008; 18(2):145-50. DOI: 10.1007/s11695-007-9315-8. View

18.

Vilarrasa N, San Jose P, Garcia I, Gomez-Vaquero C, Miras P, de Gordejuela A . Evaluation of bone mineral density loss in morbidly obese women after gastric bypass: 3-year follow-up. Obes Surg. 2010; 21(4):465-72. DOI: 10.1007/s11695-010-0338-1. View

19.

Samuel L, Borrell L . The effect of body mass index on optimal vitamin D status in U.S. adults: the National Health and Nutrition Examination Survey 2001-2006. Ann Epidemiol. 2013; 23(7):409-14. DOI: 10.1016/j.annepidem.2013.05.011. View

20.

Fish E, Beverstein G, Olson D, Reinhardt S, Garren M, Gould J . Vitamin D status of morbidly obese bariatric surgery patients. J Surg Res. 2010; 164(2):198-202. DOI: 10.1016/j.jss.2010.06.029. View