Chronic Gastritis

Overview

Journal Scand J Gastroenterol

Publisher Informa Healthcare

Specialty Gastroenterology

Date 2015 Apr 23

PMID 25901896

Citations 108

Authors

Pentti Sipponen

Heidi-Ingrid Maaroos

Affiliations

Soon will be listed here.

Abstract

Prevalence of chronic gastritis has markedly declined in developed populations during the past decades. However, chronic gastritis is still one of the most common serious pandemic infections with such severe killing sequelae as peptic ulcer or gastric cancer. Globally, on average, even more than half of people may have a chronic gastritis at present. Helicobacter pylori infection in childhood is the main cause of chronic gastritis, which microbial origin is the key for the understanding of the bizarre epidemiology and course of the disease. A life-long and aggressive inflammation in gastritis results in destruction (atrophic gastritis) of stomach mucosa with time (years and decades). The progressive worsening of atrophic gastritis results subsequently in dysfunctions of stomach mucosa. Atrophic gastritis will finally end up in a permanently acid-free stomach in the most extreme cases. Severe atrophic gastritis and acid-free stomach are the highest independent risk conditions for gastric cancer known so far. In addition to the risks of malignancy and peptic ulcer, acid-free stomach and severe forms of atrophic gastritis may associate with failures in absorption of essential vitamins, like vitamin B12, micronutrients (like iron, calcium, magnesium and zinc), diet and medicines.

Citing Articles

Common occurrence of atrophic gastritis in an ageing non-hospitalised population: an autopsy study.

Karhunen P, Tuomisto S, Goebeler S, Martiskainen M, Kok E Age Ageing. 2025; 54(3).

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Monitoring the follow-up of autoimmune chronic atrophic gastritis using parietal cell antibodies and markers of gastric function.

Panozzo M, Antico A, Bizzaro N J Transl Autoimmun. 2025; 10:100273.

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Efficacy and safety of LiWei capsule in chronic non-atrophic gastritis with erosions: a randomized controlled trial.

Cui D, Geng X, Wang J, Han X, Huang Z, Jiang M Sci Rep. 2025; 15(1):1620.

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The association of Helicobacter pylori infection with the risk of anemia in children: systematic review and meta-analysis.

Walle M, Tesfaye A, Agidew M, Semaw M, Mekuria S, Getu F BMC Infect Dis. 2025; 25(1):23.

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Can GastroPanel be used as a triage tool to select patients with advanced atrophic gastritis for gastroscopy? A prospective clinical validation study.

Papadia C, Marelli L, Wood E, Novelli M, Feakins R, Syrjanen K BMJ Open Gastroenterol. 2025; 12(1.

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