Results of the National Lung Cancer Screening Trial: Where Are We Now?
Overview
Pulmonary Medicine
Authors
Affiliations
The National Lung Screening Trial was a large, multicenter, randomized controlled trial published in 2011. It found that annual screening with low-dose CT (LDCT) in a high-risk population was associated with a 20% reduction in lung cancer-specific mortality compared with conventional chest radiography. Several leading professional organizations have since put forth lung cancer screening guidelines that include the use of LDCT, largely on the basis of this study. Broad adoption of these screening recommendations, however, remains a challenge.
Lung Cancer-Epidemiology, Pathogenesis, Treatment and Molecular Aspect (Review of Literature).
Smolarz B, Lukasiewicz H, Samulak D, Piekarska E, Kolacinski R, Romanowicz H Int J Mol Sci. 2025; 26(5).
PMID: 40076671 PMC: 11900952. DOI: 10.3390/ijms26052049.
Morris M, Habib S, Do Valle M, Schneider J J Health Econ Outcomes Res. 2025; 11(2):74-79.
PMID: 39810799 PMC: 11731590. DOI: 10.36469/001c.121512.
Vascular Biomarkers for Pulmonary Nodule Malignancy: Arteries vs. Veins.
Yu T, Zhao X, Leader J, Wang J, Meng X, Herman J Cancers (Basel). 2024; 16(19.
PMID: 39409894 PMC: 11476001. DOI: 10.3390/cancers16193274.
The Effect of COVID-19 on Lung Cancer Screening.
Thiruppathi N, Humphries N, Johnson S, Tunison L, Pippas A Cureus. 2024; 16(9):e68986.
PMID: 39385861 PMC: 11463903. DOI: 10.7759/cureus.68986.
Van De Luecht M, Reed W J Med Radiat Sci. 2021; 68(2):175-185.
PMID: 33556995 PMC: 8168065. DOI: 10.1002/jmrs.456.