Mannose Binding Lectin (MBL) 2 Gene Polymorphism & Its Association with Clinical Manifestations in Systemic Lupus Erythematosus (SLE) Patients from Western India

Overview

Journal Indian J Med Res

Specialty General Medicine

Date 2015 Apr 23

PMID 25900955

Citations 3

Authors

Vandana Pradhan

Prathamesh Surve

Anjali Rajadhyaksha

Vinod Rajendran

Manisha Patwardhan

Vinod Umare

Kanjaksha Ghosh

Anita Nadkarni

Affiliations

Soon will be listed here.

Abstract

Background & Objectives: Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by production of autoantibodies. Mannose binding lectin (MBL) is an important element of the innate defense system. t0 he present study was undertaken to determine whether variant alleles in MBL2 gene were associated with disease severity in SLE patients.

Methods: The MBL alleles [-550, -221, +4, Codon 52, Codon 54 and Codon 57] were studied by PCR- RFLP (restriction fragment length polymorphism) method in 100 SLE patients fulfilling ACR (American College of Rheumatology) criteria along with 100 healthy controls. SLE disease activity was evaluated using SLE Disease Activity Index (SLEDAI) score.

Results: Homozygosity for MBL variant allele (O/O) was observed in 24 per cent of the SLE patients compared to 16 per cent of the normal controls, while no difference was found for heterozygosity (A/O) (37 vs 35%). A significant difference was reported in incidence of double heterozygosity for mutant allele B and D (B/D) among SLE patients as against control group ( p = 0.015). MBL genotypes did not show any association with renal involvement.

Interpretation & Conclusions: In this study from western India, MBL gene polymorphism showed an influence as a possible risk factor for susceptibility to SLE, but had no direct effect on disease characteristics. Further studies need to be done on a larger number of SLE patients in different regions of the country.

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