Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study

Overview

Journal J Nerv Ment Dis

Specialties Neurology
Psychiatry

Date 2015 Apr 23

PMID 25900547

Citations 38

Authors

Camice J Revier

Ulrich Reininghaus

Rina Dutta

Paul Fearon

Robin M Murray

Gillian A Doody

Tim Croudace

Paola Dazzan

Margaret Heslin

Adanna Onyejiaka

Eugenia Kravariti

Julia Lappin

Ben Lomas

James B Kirkbride

Kim Donoghue

Craig Morgan

Peter B Jones

Affiliations

Soon will be listed here.

Abstract

It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the ÆSOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90% when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described.

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