Dynamic Responses of Selective Brain White Matter Fiber Tracts to Binge Alcohol and Recovery in the Rat

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Apr 21

PMID 25894968

Citations 9

Authors

Adolf Pfefferbaum

Natalie M Zahr

Dirk Mayer

Torsten Rohlfing

Edith V Sullivan

Affiliations

Soon will be listed here.

Abstract

To determine the dynamics of white matter vulnerability to excessive alcohol consumption, diffusion tensor imaging (DTI) was used in an animal model of alcohol exposure. Quantitative, in vivo fiber tracking results are presented from rats with DTI conducted at 3 time points: baseline; after 4 days of intragastric alcohol to blood alcohol levels of ~250 mg/dL; and after one week of recovery. Binge alcohol followed by a week of sobriety resulted in rapidly reversible decreases in fractional anisotropy (FA), a measure of the coherence of fiber tracts, in callosal genu and fimbria-fornix but not splenium; and increases in mean diffusivity (MD), an index of freely diffusing water in tissue, selective to the fimbria-fornix. These effects were confirmed with tract-based spatial statistics (TBSS). The directionality of changes in DTI metrics reproduce those observed in human alcoholism. That a single exposure to binge alcohol can cause substantial transient changes detectable in DTI metrics demonstrates the potential for rapid neuroplasticity.

Citing Articles

Alcohol-induced damage to the fimbria/fornix reduces hippocampal-prefrontal cortex connection during early abstinence.

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Alcohol use disorder: Neuroimaging evidence for accelerated aging of brain morphology and hypothesized contribution to age-related dementia.

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Age differences in brain structural and metabolic responses to binge ethanol exposure in fisher 344 rats.

Zahr N, Sullivan E, Pohl K, Pfefferbaum A Neuropsychopharmacology. 2020; 46(2):368-379.

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Neuroimaging in alcohol use disorder: From mouse to man.

Fritz M, Klawonn A, Zahr N J Neurosci Res. 2019; 100(5):1140-1158.

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Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence.

De Santis S, Bach P, Perez-Cervera L, Cosa-Linan A, Weil G, Vollstadt-Klein S JAMA Psychiatry. 2019; 76(7):749-758.

PMID: 30942831 PMC: 6583663. DOI: 10.1001/jamapsychiatry.2019.0318.

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