Molecular and Cellular Mechanisms That Initiate Pain and Itch

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2015 Apr 21

PMID 25894692

Citations 45

Authors

Jialie Luo

Jing Feng

Shenbin Liu

Edgar T Walters

Hongzhen Hu

Affiliations

Soon will be listed here.

Abstract

Somatosensory neurons mediate our sense of touch. They are critically involved in transducing pain and itch sensations under physiological and pathological conditions, along with other skin-resident cells. Tissue damage and inflammation can produce a localized or systemic sensitization of our senses of pain and itch, which can facilitate our detection of threats in the environment. Although acute pain and itch protect us from further damage, persistent pain and itch are debilitating. Recent exciting discoveries have significantly advanced our knowledge of the roles of membrane-bound G protein-coupled receptors and ion channels in the encoding of information leading to pain and itch sensations. This review focuses on molecular and cellular events that are important in early stages of the biological processing that culminates in our senses of pain and itch.

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