Tumor Suppression Function of FoxD3 in Lung Cancer

Overview

Journal Ir J Med Sci

Specialty General Medicine

Date 2015 Apr 21

PMID 25894280

Citations 6

Authors

C Wang

Y Huang

W Dai

Affiliations

Soon will be listed here.

Abstract

Introduction: The transcription factor forkhead box D3 (FoxD3) is a forkhead protein and serves as a transcriptional repressor. The functions of FoxD3 in embryogenesis and in the development of neural crest cells have been diversely studied. Its role associated with tumor development has attracted attention just in recent years. However, little is known about its regulation and functions in the tumorigenesis and progression of lung cancer.

Materials And Methods: We did a pioneer study to identify the function of FoxD3 in lung cancer by knocking down FoxD3 expression in lung adenocarcinoma cell lines.

Results: The result showed that silencing FoxD3 in lung cancer cell lines stimulated cell growth and inhibited cell apoptosis. Through quantified PCR analysis, we observed marked gene expression increase of insulin-like growth factor receptor 1 and BRAF under the condition of FoxD3 silencing. In contrast, cell cycle negative regulator P21 expression decreased after FoxD3 silencing.

Conclusions: Our study is the first to identify the tumor suppressor function of FoxD3 in lung cancer.

Citing Articles

FOXD3 confers chemo-sensitivity in ovarian cancer through a miR-335/DAAM1/myosin II axis-dependent mechanism.

Wang S, Ma Y, Hu Y, Zhao X, Li Y, Ouyang S J Ovarian Res. 2023; 16(1):8.

PMID: 36627652 PMC: 9830800. DOI: 10.1186/s13048-022-01077-y.

LncRNA FOXD3-AS1 promoted chemo-resistance of NSCLC cells via directly acting on miR-127-3p/MDM2 axis.

Zeng Z, Zhao G, Zhu H, Nie L, He L, Liu J Cancer Cell Int. 2020; 20:350.

PMID: 32742197 PMC: 7388492. DOI: 10.1186/s12935-020-01402-9.

Serum Fork-Head Box D3 (FOXD3) Expression Is Down-Regulated in and Associated with Diagnosis of Patients with Non-Small Cell Lung Cancer.

Xu B, Zhang L, Zhang D, Song C, Tian D, Jiang W Med Sci Monit. 2019; 24:9504-9508.

PMID: 30596382 PMC: 6324864. DOI: 10.12659/MSM.896748.

Screening of targets in lung cancer via bioinformatics analysis.

Jiang W, Liu P, Li X Oncol Lett. 2018; 15(3):3214-3220.

PMID: 29435060 PMC: 5778806. DOI: 10.3892/ol.2017.7685.

FOXD3 Regulates CSC Marker, DCLK1-S, and Invasive Potential: Prognostic Implications in Colon Cancer.

Sarkar S, OConnell M, Okugawa Y, Lee B, Toiyama Y, Kusunoki M Mol Cancer Res. 2017; 15(12):1678-1691.

PMID: 28851816 PMC: 5748292. DOI: 10.1158/1541-7786.MCR-17-0287.

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