Establishment of a Human Glioma Cell Line Bearing a Homogeneously Staining Chromosomal Region and Releasing Alpha- and Beta-type Transforming Growth Factors

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1989 Jan 1

PMID 2589023

Citations 4

Authors

H Kanno

T Kuwabara

M Shinonaga

C C Chang

Y Tanaka

Y Sugio

H Morita

H Yasumitsu

M Umeda

Y Nagashima

Affiliations

Soon will be listed here.

Abstract

A human glioma cell line (YKG1), which was positively identified for glial fibrillary acidic (GFA) and S-100 proteins, was established from a surgical specimen of a patient with glioblastoma. Chromosome analysis of the cells revealed a homogeneously staining region (HSR) on a marker chromosome. The assay for transforming growth factors (TGFs) in the conditioned medium of the cell line revealed that it contained high levels of alpha- and beta-type TGFs, which might regulate the growth of glioblastoma and influence on the peritumoral tissues.

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