Meta-analysis of Associations Between Neutrophil-to-lymphocyte Ratio and Prognosis of Gastric Cancer

Overview

Journal World J Surg Oncol

Publisher Biomed Central

Specialties General Surgery
Oncology

Date 2015 Apr 19

PMID 25889889

Citations 31

Authors

Jing Chen

Dongsheng Hong

You Zhai

Peng Shen

Affiliations

Soon will be listed here.

Abstract

Background: The prognostic role of inflammation indices, such as the neutrophil-to-lymphocyte ratio (NLR) in gastric cancer (GC) remains controversial. We conducted a meta-analysis to determine the predictable value of NLR in the clinical outcome of GC patients.

Methods: We searched Embase, PubMed and the Cochrane Library database for relevant randomised controlled trials. Statistical analyses were conducted to calculate the hazard ratio (HR) and 95% confidence intervals of overall survival (OS) and progression-free survival (PFS) using either random-effect or fixed-effect models according to the heterogeneity of the included studies. An analysis was carried out based on data from nine studies to evaluate the association between NLR and OS in patients with GC.

Results: Our analysis indicated that elevated pre-treatment NLR predicted poorer OS (HR: 2.16, 95% CI: 1.86 to 2.51, P < 0.001) and PFS (HR 2.78, 95% CI: 1.95 to 3.96; P < 0.00001) in patients with GC. Over a 3-year follow-up period, high NLR was a significant predictor of poor outcomes at year 1 (HR 1.99; 95% CI: 1.39 to 2.85; P = 0.0002), year 2 (HR 2.24; 95% CI: 1.69 to 2.97; P < 0.00001) and year 3 (HR 2.80; 95% CI: 1.98 to 3.96; P < 0.00001).

Conclusions: Elevated preoperative NLR is associated with poorer rates of survival in GC patients and may play a role in GC surveillance programmes as a means of delivering more personalised cancer care.

Citing Articles

Dysregulation of systemic immunity and its clinical application in gastric cancer.

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A nomogram combining neutrophil to lymphocyte ratio (NLR) and prognostic nutritional index (PNI) to predict distant metastasis in gastric cancer.

Liu J, Sun R, Cai K, Xu Y, Yuan W Sci Rep. 2024; 14(1):15391.

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Preoperative High C-Reactive Protein to Albumin Ratio Predicts Short- and Long-Term Postoperative Outcomes in Elderly Gastric Cancer Patients.

Takemoto Y, Tanabe K, Chikuie E, Saeki Y, Ota H, Karakuchi N Cancers (Basel). 2024; 16(3).

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Prognostic Role of Preoperative Neutrophil-To-Lymphocyte Ratio (NLR) and Recurrence at First Evaluation after Bacillus Calmette-Guérin (BCG) Induction in Non-Muscle-Invasive Bladder Cancer.

Lee J, Yoo S, Choo M, Cho M, Son H, Jeong H Diagnostics (Basel). 2023; 13(19).

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Impact of serum albumin concentration and neutrophil-lymphocyte ratio score on gastric cancer prognosis.

Costa T, Nogueiro J, Ribeiro D, Viegas P, Santos-Sousa H Langenbecks Arch Surg. 2023; 408(1):57.

PMID: 36689025 DOI: 10.1007/s00423-023-02799-3.

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