The Non-coding RNAs of the H19-IGF2 Imprinted Loci: a Focus on Biological Roles and Therapeutic Potential in Lung Cancer

Overview

Journal J Transl Med

Publisher Biomed Central

Specialties Biomedical Engineering
General Medicine

Date 2015 Apr 18

PMID 25884481

Citations 48

Authors

Imad J Matouk

David Halle

Michal Gilon

Abraham Hochberg

Affiliations

Soon will be listed here.

Abstract

Since it was first described, the imprinted cluster 11p15.5 has been reported to be deregulated in a variety of pediatric and adult cancers including that of the lung. Both protein coding and non-coding genes functioning as oncogenes or as tumor suppressor genes reside within this cluster. Oncomirs that can function as oncogenes or as tumor suppressors have also been reported. While a complete account of the role played by the 11p15.5 imprinted cluster in lung cancer is beyond the scope of this review, we will focus on the role of the non-coding RNAs processed from the H19-IGF2 loci. A special emphasis will be given to the H19/miR-675 gene locus. Their potential diagnostic and therapeutic use in lung cancer will be described.

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