The Role of Death-associated Protein 3 in Apoptosis, Anoikis and Human Cancer

Overview

Journal Cancer Cell Int

Publisher Biomed Central

Date 2015 Apr 18

PMID 25883535

Citations 19

Authors

Umar Wazir

Mona Maw Orakzai

Zubair S Khanzada

Wen G Jiang

Anup K Sharma

Abdul Kasem

Kefah Mokbel

Affiliations

Soon will be listed here.

Abstract

Death-associated protein 3 (DAP3) is a molecule with a significant role in the control of both apoptosis and anoikis. Apoptosis is the predominant type of programmed cell death (PCD) which may occur in response to irreparable damage to DNA, or in response to induction by inflammatory cells. Anoikis is subset of apoptosis which occurs in epithelial cells in response to detachment from the surrounding matrix. Both apoptosis and anoikis are of interest in the context of carcinogenesis. In this review, we shall discuss apoptosis and anoikis, and the recent literature regarding the role of DAP3 in both these pathways.

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