Genetic Polymorphisms Associated with Breast Cancer in Malaysian Cohort

Overview

Journal Indian J Clin Biochem

Specialty Biochemistry

Date 2015 Apr 18

PMID 25883419

Citations 8

Authors

Jagdish Kaur Chahil

Khamsigan Munretnam

Nurulhafizah Samsudin

Say Hean Lye

Nikman Adli Nor Hashim

Nurul Hanis Ramzi

Sharmila Velapasamy

Ler Lian Wee

Livy Alex

Affiliations

Soon will be listed here.

Abstract

Genome-wide association studies have discovered multiple single nucleotide polymorphisms (SNPs) associated with the risk of common diseases. The objective of this study was to demonstrate the replication of previously published SNPs that showed statistical significance for breast cancer in the Malaysian population. In this case-control study, 80 subjects for each group were recruited from various hospitals in Malaysia. A total of 768 SNPs were genotyped and analyzed to distinguish risk and protective alleles. A total of three SNPs were found to be associated with increased risk of breast cancer while six SNPs showed protective effect. All nine were statistically significant SNPs (p ≤ 0.01), five SNPs from previous studies were successfully replicated in our study. Significant modifiable (diet) and non-modifiable (family history of breast cancer in first degree relative) risk factors were also observed. We identified nine SNPs from this study to be either conferring susceptibility or protection to breast cancer which may serve as potential markers in risk prediction.

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