The Effect of Vitamin D on Vaginal Atrophy in Postmenopausal Women

Overview

Journal Iran J Nurs Midwifery Res

Specialty Nursing

Date 2015 Apr 17

PMID 25878698

Citations 17

Authors

Parastou Rad

Mitra Tadayon

Mohammadreza Abbaspour

Seyed Mahmood Latifi

Iran Rashidi

Hamdollah Delaviz

Affiliations

Soon will be listed here.

Abstract

Background: Most of the women suffer from vaginal atrophy and dryness, and therefore, efficient and safe treatment is needed to improve vaginal lubrication. Vitamin D has several important functions which may be effective in proliferation and repair of the epithelial tissue. This study aimed to evaluate the effect of vitamin D vaginal suppositories on maturation index, pH, and dryness in postmenopausal women.

Materials And Methods: Women were enrolled in this double-blind clinical trial, in whom menopause occurred at least one year ago. Those women who had an abnormal Papanicolaou smear, had undergone hormonal treatment, or have had vaginal infection in the previous year were excluded. Forty-four women who found eligible were randomized into two equal groups, the treatment and control groups, which received vitamin D and placebo vaginal suppository daily for 8 weeks, respectively. Vaginal pH and maturation value were measured at the beginning and end of the study. Pain, dryness, and paleness were assessed before treatment and at the end of the 2, 4, and 8 weeks of treatment.

Results: In the treatment group, the number (Mean ± SD) of superficial cells increased (69.76 ± 12.4) and vaginal pH decreased (1.42 ± 0.67) significantly compared to the control group after 56 days. The mean pain significantly reduced after 8 weeks in the treatment group (1.23 ± 0.53) compared to the control group 1.95 ± 0.74 (P < 0.001). The mean of dryness and paleness reduced significantly in the treatment group versus control at 56 days.

Conclusions: Vitamin D is effective in improving the maturation index and decreased the pH and dryness of the vaginal atrophy due to menopause.

Citing Articles

Effect of Vitamin D Level on Female Vaginitis in Xi'an, China.

Guan J, Dong Y, Zhang W, Gui Q, Luo D, Wen H Int J Womens Health. 2024; 16:2103-2112.

PMID: 39659295 PMC: 11630696. DOI: 10.2147/IJWH.S481539.

Effect of Vitamin D on the Proliferation and Barrier of Atrophic Vaginal Epithelial Cells.

Li D, Zhang T, Yang H, Yang W, Zhang C, Gao G Molecules. 2023; 28(18).

PMID: 37764381 PMC: 10535479. DOI: 10.3390/molecules28186605.

Therapeutic Effects of Vitamin D on Vaginal, Sexual, and Urological Functions in Postmenopausal Women.

Hassanein M, Huri H, Abduelkarem A, Baig K Nutrients. 2023; 15(17).

PMID: 37686835 PMC: 10490181. DOI: 10.3390/nu15173804.

The role of vitamin D in menopausal women's health.

Mei Z, Hu H, Zou Y, Li D Front Physiol. 2023; 14:1211896.

PMID: 37378077 PMC: 10291614. DOI: 10.3389/fphys.2023.1211896.

The effect of conjugated estrogens vaginal cream and a combined vaginal cream of vitamins D and E in the treatment of genitourinary syndrome.

Radnia N, Hosseini S, Vafaei S, Pirdehghan A, Mehrabadi N J Family Med Prim Care. 2023; 12(3):507-516.

PMID: 37122641 PMC: 10131947. DOI: 10.4103/jfmpc.jfmpc_1364_22.

References

Pittas A, Lau J, Hu F, Dawson-Hughes B . The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007; 92(6):2017-29. PMC: 2085234. DOI: 10.1210/jc.2007-0298. View

Zhu X, Wang B, Zhao G, Gu J, Chen Z, Briantais P . An investigator-masked comparison of the efficacy and safety of twice daily applications of calcitriol 3 microg/g ointment vs. calcipotriol 50 microg/g ointment in subjects with mild to moderate chronic plaque-type psoriasis. J Eur Acad Dermatol Venereol. 2007; 21(4):466-72. DOI: 10.1111/j.1468-3083.2006.01913.x. View

NOTELOVITZ M, Funk S, Nanavati N, Mazzeo M . Estradiol absorption from vaginal tablets in postmenopausal women. Obstet Gynecol. 2002; 99(4):556-62. DOI: 10.1016/s0029-7844(01)01385-0. View

Yildirim B, Kaleli B, Duzcan E, Topuz O . The effects of postmenopausal Vitamin D treatment on vaginal atrophy. Maturitas. 2004; 49(4):334-7. DOI: 10.1016/j.maturitas.2004.02.008. View

Motiwala S, Wang T . Vitamin D and cardiovascular risk. Curr Hypertens Rep. 2012; 14(3):209-18. DOI: 10.1007/s11906-012-0262-y. View

Berman J, Adhikari S, Goldstein I . Anatomy and physiology of female sexual function and dysfunction: classification, evaluation and treatment options. Eur Urol. 2000; 38(1):20-9. DOI: 10.1159/000020247. View

van der Laak J, de Bie L, de Leeuw H, de Wilde P, Hanselaar A . The effect of Replens on vaginal cytology in the treatment of postmenopausal atrophy: cytomorphology versus computerised cytometry. J Clin Pathol. 2002; 55(6):446-51. PMC: 1769660. DOI: 10.1136/jcp.55.6.446. View

NACHTIGALL L . Comparative study: Replens versus local estrogen in menopausal women. Fertil Steril. 1994; 61(1):178-80. DOI: 10.1016/s0015-0282(16)56474-7. View

Pritchard K . The role of hormone replacement therapy in women with a previous diagnosis of breast cancer and a review of possible alternatives. Ann Oncol. 2001; 12(3):301-10. DOI: 10.1023/a:1011197007606. View

10.

Bikle D, Teichert A, Hawker N, Xie Z, Oda Y . Sequential regulation of keratinocyte differentiation by 1,25(OH)2D3, VDR, and its coregulators. J Steroid Biochem Mol Biol. 2007; 103(3-5):396-404. DOI: 10.1016/j.jsbmb.2006.12.063. View

11.

Yildirim B, Abban G, Erdogan B . Immunohistochemical detection of 1,25-dihydroxyvitamin D receptor in rat vaginal epithelium. Fertil Steril. 2004; 82(6):1602-8. DOI: 10.1016/j.fertnstert.2004.07.949. View

12.

Meisels A . The maturation value. Acta Cytol. 1967; 11(4):249. View

13.

Skarin A, Sylwan J . Vaginal lactobacilli inhibiting growth of Gardnerella vaginalis, Mobiluncus and other bacterial species cultured from vaginal content of women with bacterial vaginosis. Acta Pathol Microbiol Immunol Scand B. 1986; 94(6):399-403. DOI: 10.1111/j.1699-0463.1986.tb03074.x. View

14.

Reiter S . Barriers to effective treatment of vaginal atrophy with local estrogen therapy. Int J Gen Med. 2013; 6:153-8. PMC: 3603331. DOI: 10.2147/IJGM.S43192. View

15.

Grodstein F, Stampfer M . The epidemiology of coronary heart disease and estrogen replacement in postmenopausal women. Prog Cardiovasc Dis. 1995; 38(3):199-210. DOI: 10.1016/s0033-0620(95)80012-3. View

16.

Castelo-Branco C, Cancelo M, Villero J, Nohales F, Julia M . Management of post-menopausal vaginal atrophy and atrophic vaginitis. Maturitas. 2005; 52 Suppl 1:S46-52. DOI: 10.1016/j.maturitas.2005.06.014. View

17.

Checa M, Garrido A, Prat M, Conangla M, Rueda C, Carreras R . A comparison of raloxifene and calcium plus vitamin D on vaginal atrophy after discontinuation of long-standing postmenopausal hormone therapy in osteoporotic women. A randomized, masked-evaluator, one-year, prospective study. Maturitas. 2005; 52(1):70-7. DOI: 10.1016/j.maturitas.2004.12.006. View

18.

Bygdeman M, Swahn M . Replens versus dienoestrol cream in the symptomatic treatment of vaginal atrophy in postmenopausal women. Maturitas. 1996; 23(3):259-63. DOI: 10.1016/0378-5122(95)00955-8. View

19.

Derzko C, Elliott S, Lam W . Management of sexual dysfunction in postmenopausal breast cancer patients taking adjuvant aromatase inhibitor therapy. Curr Oncol. 2008; 14 Suppl 1:S20-40. PMC: 2140180. DOI: 10.3747/co.2007.151. View

20.

Minkin M, Maamari R, Reiter S . Improved compliance and patient satisfaction with estradiol vaginal tablets in postmenopausal women previously treated with another local estrogen therapy. Int J Womens Health. 2013; 5:133-9. PMC: 3604875. DOI: 10.2147/IJWH.S41897. View