Gamma Activity Model for Treatment-resistant Bipolar Psychotic Mania

Overview

Journal Indian J Pharmacol

Specialty Pharmacology

Date 2015 Apr 17

PMID 25878386

Citations 1

Authors

Shashi Ranjan Kumar

Vinod Kumar Sinha

Sai Krishna Tikka

Nishant Goyal

Affiliations

Soon will be listed here.

Abstract

Objectives: The objective was to investigate the effect of clozapine on spontaneous gamma activity in treatment-resistant bipolar psychotic mania.

Methods: Patients with treatment-resistant (TR) bipolar psychotic mania on clozapine monotherapy and nontreatment-resistant bipolar psychotic mania patients receiving lithium were prospectively studied for 6 weeks on severity of psychopathology and 30-49 Hz gamma spectral power.

Results: Spectral power significantly increased in the lithium group and decreased in the clozapine group; no within group significant difference found.

Conclusions: We propose a model highlighting the role of gamma spectral power and modulations of GABAergic neurotransmission in TR bipolar psychotic mania.

Citing Articles

Challenges in defining treatment-resistant mania in adults: A systematic review.

Gonzalez-Torres C, Mulsant B, Husain M, Alda M, Young R, Ortiz A Bipolar Disord. 2023; 26(1):7-21.

PMID: 37963496 PMC: 10922285. DOI: 10.1111/bdi.13383.

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