Radiotherapy Complements Immune Checkpoint Blockade

Overview

Journal Cancer Cell

Publisher Cell Press

Specialty Oncology

Date 2015 Apr 16

PMID 25873170

Citations 29

Authors

Shin Foong Ngiow

Grant A McArthur

Mark J Smyth

Affiliations

Soon will be listed here.

Abstract

Adaptive immune resistance ablates effective anti-tumor immune responses. In a recent issue of Nature, Victor and colleagues describe that anti-PD-L1 combats adaptive immune resistance upon localized radiation plus anti-CTLA-4 therapy. The superior activity of radiation and dual immune checkpoint blockade is mediated by non-redundant immune mechanisms in cancer.

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