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Amino Acid Substitutions Contributing to α2,6-sialic Acid Linkage Binding Specificity of Human Parainfluenza Virus Type 3 Hemagglutinin-neuraminidase

Overview
Journal FEBS Lett
Specialty Biochemistry
Date 2015 Apr 15
PMID 25871520
Citations 5
Authors
Keijo Fukushima
Tadanobu Takahashi
Hiroo Ueyama
Masahiro Takaguchi
Seigo Ito
Kenta Oishi
Akira Minami
Erika Ishitsubo
Hiroaki Tokiwa
Toru Takimoto
Takashi Suzuki
Affiliations
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Abstract

Human parainfluenza virus type 3 (hPIV3) recognizes both α2,3- and α2,6-linked sialic acids, whereas human parainfluenza virus type 1 (hPIV1) recognizes only α2,3-linked sialic acids. To identify amino acid residues that confer α2,6-linked sialic acid recognition of hPIV3, amino acid residues in or neighboring the sialic acid binding pocket of the hPIV3 hemagglutinin-neuraminidase (HN) glycoprotein were substituted for the corresponding residues of hPIV1 HN. Hemadsorption assay with sialyl linkage-modified red blood cells indicated that amino acid residues at positions 275, 277, 372, and 426 contribute to α2,6-linked sialic acid recognition of the HN3 glycoprotein.

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References
1.
Fukushima K, Takahashi T, Ito S, Takaguchi M, Takano M, Kurebayashi Y . Terminal sialic acid linkages determine different cell infectivities of human parainfluenza virus type 1 and type 3. Virology. 2014; 464-465:424-431. DOI: 10.1016/j.virol.2014.07.033. View
2.
Vines A, Wells K, Matrosovich M, Castrucci M, Ito T, Kawaoka Y . The role of influenza A virus hemagglutinin residues 226 and 228 in receptor specificity and host range restriction. J Virol. 1998; 72(9):7626-31. PMC: 110023. DOI: 10.1128/JVI.72.9.7626-7631.1998. View
3.
Henrickson K . Parainfluenza viruses. Clin Microbiol Rev. 2003; 16(2):242-64. PMC: 153148. DOI: 10.1128/CMR.16.2.242-264.2003. View
4.
Muthing J, Unland F . A comparative assessment of TLC overlay technique and microwell adsorption assay in the examination of influenza A and Sendai virus specificities towards oligosaccharides and sialic acid linkages of gangliosides. Glycoconj J. 1994; 11(5):486-92. DOI: 10.1007/BF00731285. View
5.
Suzuki Y . Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses. Biol Pharm Bull. 2005; 28(3):399-408. DOI: 10.1248/bpb.28.399. View