Living Without Insulin: the Role of Leptin Signaling in the Hypothalamus

Overview

Journal Front Neurosci

Date 2015 Apr 15

PMID 25870537

Citations 10

Authors

Teppei Fujikawa

Roberto Coppari

Affiliations

Soon will be listed here.

Abstract

Since its discovery in 1922, insulin has been thought to be required for normal metabolic homeostasis and survival. However, this view would need to be revised as recent results from different laboratories have convincingly indicated that life without insulin is possible in rodent models. These data indicate that particular neuronal circuitries, which include hypothalamic leptin-responsive neurons, are empowered with the capability of permitting life in complete absence of insulin. Here, we review the neuronal and peripheral mechanisms by which leptin signaling in the central nervous system (CNS) regulates glucose metabolism in an insulin-independent manner.

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