Genetic and Treatment-related Risk Factors Associated with External Apical Root Resorption (EARR) Concurrent with Orthodontia

Overview

Journal Orthod Craniofac Res

Specialty Dentistry

Date 2015 Apr 14

PMID 25865535

Citations 32

Authors

L Y Sharab

L A Morford

J Dempsey

G Falcao-Alencar

A Mason

E Jacobson

G T Kluemper

J V Macri

J K Hartsfield Jr

Affiliations

Soon will be listed here.

Abstract

Objective: As genetic variation accounts for two-thirds of the variation in external apical root resorption (EARR) concurrent with orthodontic treatment, we analyzed the association of selected genetic and treatment-related factors with EARR concurrent with orthodontic treatment.

Setting And Sample Population: This case-control study of 134 unrelated, orthodontically treated Caucasian individuals was conducted in part at an Indiana Private Practice, Indiana University and the University of Kentucky.

Methods: Utilizing a research data bank containing information from ~1450 orthodontically treated patients, pre- and post-treatment radiographs from 460 individuals were evaluated for EARR of the four permanent maxillary incisors. Sixty-seven unrelated Caucasians with moderate to severe EARR were identified and were age-/sex-matched with orthodontically treated Caucasian controls yielding 38 females and 29 males per group. Factors tested for an association with EARR included the following: 1) treatment duration, 2) extraction of maxillary premolars, 3) numerous cephalometric measurements, and 4) DNA polymorphisms within/near candidate genes in a pathway previously implicated in EARR such as the purinergic-receptor-P2X, ligand-gated ion channel 7 (P2RX7; rs208294, rs1718119, and rs2230912), caspase-1 (CASP1; rs530537, rs580253, and rs554344), interleukin-1 beta (IL1B; rs1143634), interleukin-1 alpha (IL1A; rs1800587), and interleukin-1 receptor antagonist (IL1RA; rs419598) genes. Stepwise logistic regression was utilized to identify the factors significantly associated (significance taken at or less than the layered Bonferroni correction alpha) with the occurrence of EARR.

Results: A long length of treatment and the presence of specific genotypes for P2RX7 SNP rs208294 were significantly associated with EARR.

Conclusion: EARR occurrence was associated with both genetic and treatment-related variables, which together explained 25% of the total variation associated with EARR in the sample tested.

Citing Articles

Investigation of the association between COX-2 polymorphisms and external apical root resorption in orthodontically treated patients.

Pinheiro L, Maranon-Vasquez G, Antunes L, Proff P, Paddenbergb E, Kirschneck C Clin Oral Investig. 2024; 28(12):676.

PMID: 39617811 DOI: 10.1007/s00784-024-06064-9.

Bibliometric analysis of publications on genetic polymorphism and external apical root resorption research.

Pinheiro L, de Moura D, Antunes L, Antunes L Dental Press J Orthod. 2024; 29(4):e2423268.

PMID: 39230110 PMC: 11368243. DOI: 10.1590/2177-6709.29.4.e2423268.oar.

Genetic polymorphisms in external apical root resorption and orthodontic tooth movements: A systematic review.

Andrade A, Pinto Y, Maia B, Correa J, Miranda D, Manzi F Korean J Orthod. 2024; 54(5):284-302.

PMID: 39162020 PMC: 11422680. DOI: 10.4041/kjod24.030.

Evaluating Single-Nucleotide Polymorphisms in Inflammasome Proteins and Serum Levels of IL-18 and IL-1β in Kidney Interstitial Damage in Anti-Neutrophilic Cytoplasmic Antibody-Associated Vasculitis.

Martinez Valenzuela L, Vidal-Alabro A, Rubio B, Anton-Pampols P, Gomez-Preciado F, Fulladosa X Int J Mol Sci. 2024; 25(12).

PMID: 38928186 PMC: 11203640. DOI: 10.3390/ijms25126479.

Genetic polymorphisms linked to extreme postorthodontic external apical root resorption in Koreans.

Liu J, Park K, Choi Y, Lee J, Cha J Prog Orthod. 2024; 25(1):23.

PMID: 38853224 PMC: 11162991. DOI: 10.1186/s40510-024-00521-7.

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