Cell Biology of Yeast Zygotes, from Genesis to Budding

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2015 Apr 12

PMID 25862405

Citations 1

Authors

Alan M Tartakoff

Affiliations

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Abstract

The zygote is the essential intermediate that allows interchange of nuclear, mitochondrial and cytosolic determinants between cells. Zygote formation in Saccharomyces cerevisiae is accomplished by mechanisms that are not characteristic of mitotic cells. These include shifting the axis of growth away from classical cortical landmarks, dramatically reorganizing the cell cortex, remodeling the cell wall in preparation for cell fusion, fusing with an adjacent partner, accomplishing nuclear fusion, orchestrating two steps of septin morphogenesis that account for a delay in fusion of mitochondria, and implementing new norms for bud site selection. This essay emphasizes the sequence of dependent relationships that account for this progression from cell encounters through zygote budding. It briefly summarizes classical studies of signal transduction and polarity specification and then focuses on downstream events.

Citing Articles

A zygote-based assay to evaluate intranuclear shuttling in .

Tartakoff A STAR Protoc. 2021; 2(3):100736.

PMID: 34430911 PMC: 8365525. DOI: 10.1016/j.xpro.2021.100736.

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