Platelet-derived Growth Factors Induced Lymphangiogenesis: Evidence, Unanswered Questions and Upcoming Challenges

Overview

Journal Arch Med Sci

Specialty General Medicine

Date 2015 Apr 11

PMID 25861290

Citations 11

Authors

Andreea Adriana Jitariu

Anca Maria Cimpean

Nilima Rajpal Kundnani

Marius Raica

Affiliations

Soon will be listed here.

Abstract

Crosstalk between angiogenesis and lymphangiogenesis in embryonic development continues during postnatal life and has specific mechanisms involving factors that initiate activation of the intracellular cascade for their specific receptors. Platelet-derived growth factors (PDGFs) and their corresponding receptors (PDGFRs) are known as important regulators of blood vessel development in both normal and pathologic angiogenesis. Despite some recent papers which reported a potential role of the PDGF/PDGFR axis in lymphatic spread of tumor cells, a few papers have suggested the potential role of PDGFs in tumor lymphangiogenesis development. The present paper summarizes the potential lymphangiogenic role of the PDGF/PDGFR axis, underlying upcoming challenges in the field.

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References

Rosenkranz S, Kazlauskas A . Evidence for distinct signaling properties and biological responses induced by the PDGF receptor alpha and beta subtypes. Growth Factors. 1999; 16(3):201-16. DOI: 10.3109/08977199909002130. View

Hellstrom M, Kalen M, Lindahl P, Abramsson A, Betsholtz C . Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development. 1999; 126(14):3047-55. DOI: 10.1242/dev.126.14.3047. View

Fambrough D, McClure K, Kazlauskas A, Lander E . Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell. 1999; 97(6):727-41. DOI: 10.1016/s0092-8674(00)80785-0. View

Ferrara N . Molecular and biological properties of vascular endothelial growth factor. J Mol Med (Berl). 1999; 77(7):527-43. DOI: 10.1007/s001099900019. View

Wigle J, Oliver G . Prox1 function is required for the development of the murine lymphatic system. Cell. 1999; 98(6):769-78. DOI: 10.1016/s0092-8674(00)81511-1. View

Heldin C, Westermark B . Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev. 1999; 79(4):1283-316. DOI: 10.1152/physrev.1999.79.4.1283. View

Li X, Ponten A, Aase K, Karlsson L, Abramsson A, Uutela M . PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat Cell Biol. 2000; 2(5):302-9. DOI: 10.1038/35010579. View

Bergsten E, Uutela M, Li X, Pietras K, Ostman A, Heldin C . PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor. Nat Cell Biol. 2001; 3(5):512-6. DOI: 10.1038/35074588. View

Ferrara N . Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol. 2001; 280(6):C1358-66. DOI: 10.1152/ajpcell.2001.280.6.C1358. View

10.

Betsholtz C, Karlsson L, Lindahl P . Developmental roles of platelet-derived growth factors. Bioessays. 2001; 23(6):494-507. DOI: 10.1002/bies.1069. View

11.

Alitalo K, Carmeliet P . Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell. 2002; 1(3):219-27. DOI: 10.1016/s1535-6108(02)00051-x. View

12.

Lokker N, Sullivan C, Hollenbach S, Israel M, Giese N . Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Cancer Res. 2002; 62(13):3729-35. View

13.

Petrova T, Makinen T, Makela T, Saarela J, Virtanen I, Ferrell R . Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J. 2002; 21(17):4593-9. PMC: 125413. DOI: 10.1093/emboj/cdf470. View

14.

Hong Y, Harvey N, Noh Y, Schacht V, Hirakawa S, Detmar M . Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. Dev Dyn. 2002; 225(3):351-7. DOI: 10.1002/dvdy.10163. View

15.

Reigstad L, Sande H, Fluge O, Bruland O, Muga A, Varhaug J . Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure. J Biol Chem. 2003; 278(19):17114-20. DOI: 10.1074/jbc.M301728200. View

16.

Brennan J, Tilmann C, Capel B . Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad. Genes Dev. 2003; 17(6):800-10. PMC: 196020. DOI: 10.1101/gad.1052503. View

17.

Saharinen P, Alitalo K . Double target for tumor mass destruction. J Clin Invest. 2003; 111(9):1277-80. PMC: 154456. DOI: 10.1172/JCI18539. View

18.

Hoch R, Soriano P . Roles of PDGF in animal development. Development. 2003; 130(20):4769-84. DOI: 10.1242/dev.00721. View

19.

Hermanson M, Funa K, Hartman M, Claesson-Welsh L, Heldin C, Westermark B . Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res. 1992; 52(11):3213-9. View

20.

Oefner C, Darcy A, Winkler F, Eggimann B, Hosang M . Crystal structure of human platelet-derived growth factor BB. EMBO J. 1992; 11(11):3921-6. PMC: 556902. DOI: 10.1002/j.1460-2075.1992.tb05485.x. View