Practical Recommendations for Mixing Allergy Immunotherapy Extracts

Overview

Journal Allergy Rhinol (Providence)

Publisher Sage Publications

Specialty Allergy & Immunology

Date 2015 Apr 11

PMID 25860164

Citations 2

Authors

Barbara J Daigle

Donna J Rekkerth

Affiliations

Soon will be listed here.

Abstract

Critical aspects of formulating allergy immunotherapy vaccines include the selection, total number, and proportions of each allergen component in therapeutic mixtures. The immunotherapy prescription, determined by a medical provider, details the dosing and schedule for treatment as well as the specific composition of the treatment vials. Allergen extracts are composed of many components such as proteins, glycoproteins, and proteases. Some components in allergen extracts are cross-reactive, meaning that treatment with an extract from one species may confer partial protection against a triggering allergen from another species. Conversely, some allergen extracts are incompatible with other extracts when combined in a mixture for treatment, resulting in lowered therapeutic potential for the patient. Therefore, knowledge of allergen extract cross-reactivities and incompatibilities guides the preparation of subcutaneous immunotherapy prescriptions. In a clinical setting, an understanding of what can and can not be mixed is one critical element in improving treatment outcomes.

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Cross-reactivity in Skin Prick Test Results of Members Within Pooideae Subfamily.

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