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Whole Genome Sequencing in Pharmacogenomics

Overview
Journal Front Pharmacol
Date 2015 Apr 11
PMID 25859217
Citations 20
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Abstract

Pharmacogenomics aims to shed light on the role of genes and genomic variants in clinical treatment response. Although, several drug-gene relationships are characterized to date, many challenges still remain toward the application of pharmacogenomics in the clinic; clinical guidelines for pharmacogenomic testing are still in their infancy, whereas the emerging high throughput genotyping technologies produce a tsunami of new findings. Herein, the potential of whole genome sequencing on pharmacogenomics research and clinical application are highlighted.

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References
1.
Rasmussen-Torvik L, Stallings S, Gordon A, Almoguera B, Basford M, Bielinski S . Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems. Clin Pharmacol Ther. 2014; 96(4):482-9. PMC: 4169732. DOI: 10.1038/clpt.2014.137. View

2.
Motsinger-Reif A, Jorgenson E, Relling M, Kroetz D, Weinshilboum R, Cox N . Genome-wide association studies in pharmacogenomics: successes and lessons. Pharmacogenet Genomics. 2010; 23(8):383-94. PMC: 3003940. DOI: 10.1097/FPC.0b013e32833d7b45. View

3.
Mooney S . Progress towards the integration of pharmacogenomics in practice. Hum Genet. 2014; 134(5):459-65. PMC: 4362928. DOI: 10.1007/s00439-014-1484-7. View

4.
Drogemoller B, Wright G, Niehaus D, Emsley R, Warnich L . Whole-genome resequencing in pharmacogenomics: moving away from past disparities to globally representative applications. Pharmacogenomics. 2011; 12(12):1717-28. DOI: 10.2217/pgs.11.119. View

5.
Mizzi C, Peters B, Mitropoulou C, Mitropoulos K, Katsila T, Agarwal M . Personalized pharmacogenomics profiling using whole-genome sequencing. Pharmacogenomics. 2014; 15(9):1223-34. DOI: 10.2217/pgs.14.102. View